发明授权
- 专利标题： METHOD FOR HIGH-LEVEL SECRETION AND PRODUCTION OF PROTEIN
- 专利标题（中）： 法高浓度蛋白质分泌和产生
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申请号： EP08845087.9申请日： 2008-10-29
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公开(公告)号： EP2210940B1公开(公告)日： 2015-03-11
- 发明人: CHIBA, Yasunori , JIGAMI, Yoshifumi , TAKAHASHI, Yoshie , KURODA, Kosuke , KOBAYASHI, Kazuo , ICHIKAWA, Kimihisa , NONAKA, Koichi , SUZUKI, Takeshi , ONO, Minako
- 申请人： Daiichi Sankyo Company, Limited
- 申请人地址： 3-5-1, Nihonbashi Honcho Chuo-ku Tokyo 103-8426 JP
- 专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人地址： 3-5-1, Nihonbashi Honcho Chuo-ku Tokyo 103-8426 JP
- 代理机构： Hoffmann Eitle
- 优先权： JP2007283731 20071031; JP2007288845 20071106
- 国际公布： WO2009057813 20090507
- 主分类号： C07K14/39
- IPC分类号： C07K14/39 ; C07K14/395 ; C07K16/00 ; C12N15/67 ; C07K14/47 ; C12N9/02 ; C12N9/10 ; C12N9/14 ; C12N9/90 ; C12P21/02
摘要：
This invention provides a means for high-level secretory production of a protein, and, in particular, a protein having a complicated structure such as an antibody, in a host cell such as a yeast cell. This invention provides a method for high-level secretory production of a foreign protein with the use of a transformed host cell having one or more types of chaperone protein genes and via suppression of O sugar chain inherent to a host cell such as a yeast cell.
公开/授权文献
- EP2210940B2 METHOD FOR HIGH-LEVEL SECRETION AND PRODUCTION OF PROTEIN 公开/授权日：2018-07-18
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