发明公开
EP2211897A1 ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A)
审中-公开
经修饰的N-钙粘蛋白处理。在肿瘤细胞与弗林蛋白酶前蛋白转化酶5A（PC5A）
- 专利标题： ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A)
- 专利标题（中）： 经修饰的N-钙粘蛋白处理。在肿瘤细胞与弗林蛋白酶前蛋白转化酶5A（PC5A）
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申请号： EP08843796.7申请日： 2008-11-03
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公开(公告)号： EP2211897A1公开(公告)日： 2010-08-04
- 发明人: MARET, Deborah , COLMAN, David, R. , GRUZGLIN, Eugenia , SEIDAH, Nabil
- 申请人： The Royal Institution for the Advancement of Learning/McGill University , IRCM (Institut De Recherches Cliniques De Montreal) , Mount Sinai School Of Medicine
- 申请人地址： 1555 Peel Street, 11th Floor Montreal QC H3A 3L8 CA
- 专利权人： The Royal Institution for the Advancement of Learning/McGill University,IRCM (Institut De Recherches Cliniques De Montreal),Mount Sinai School Of Medicine
- 当前专利权人： The Royal Institution for the Advancement of Learning/McGill University,IRCM (Institut De Recherches Cliniques De Montreal),Mount Sinai School Of Medicine
- 当前专利权人地址： 1555 Peel Street, 11th Floor Montreal QC H3A 3L8 CA
- 代理机构： Weiss, Wolfgang
- 优先权： US996119P 20071101
- 国际公布： WO2009055937 20090507
- 主分类号： A61K38/43
- IPC分类号： A61K38/43 ; A61K31/7105 ; A61K49/00 ; A61P35/00 ; G01N33/53
摘要：
The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a subject by determining the molecular form of cadherin at the cell surface of cancer cells in the subject. The invention also relates to a method for preventing, inhibiting or treating cancer or its metastasis in a subject by increasing the adhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at the cell surface. The invention also relates to a method step of determining the expression level of furin and proprotein convertase 5A (PC5A).
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