发明公开
- 专利标题： ISOQUINOLINE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
- 专利标题（中）： 异喹啉AS ATP结合盒转运调节剂的
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申请号： EP08849242.6申请日： 2008-11-14
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公开(公告)号： EP2217572A1公开(公告)日： 2010-08-18
- 发明人: HADIDA RUAH, Sara , MILLER, Mark , ZHOU, Jinglan , BEAR, Brian , GROOTENHUIS, Peter, D., J.
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： 130 Waverly Street Cambridge, MA 02139 US
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： 130 Waverly Street Cambridge, MA 02139 US
- 代理机构： Cohausz & Florack
- 优先权： US988559P 20071116
- 国际公布： WO2009064959 20090522
- 主分类号： C07D217/22
- IPC分类号： C07D217/22 ; A61K31/472 ; A61K31/4725 ; A61P11/00 ; C07D401/04 ; C07D405/12 ; C07D405/14
摘要：
Compounds of the present invention, of formula (I) and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
公开/授权文献
- EP2217572B1 ISOQUINOLINE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 公开/授权日：2013-11-06
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