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1.发明授权HETEROCYCLIC MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权异烟肼调节蛋白ATP-BINDENDEN KASSETTENTRANSPORTERN
公开(公告)号：EP1945632B1
公开(公告)日：2013-09-18
申请号：EP06837028.7
申请日：2006-11-08
发明人： HADIDA RUAH, Sara , HAMILTON, Matthew , MILLER, Mark , GROOTENHUIS, Peter, D., J. , BEAR, Brian , MCCARTHY, Jason , ZHOU, Jinglan
IPC分类号： C07D405/12 , C07D405/14 , C07D213/75 , A61K31/5585 , A61K31/4418 , A61P11/00
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Pharmaceutically acceptable compositions of the present invention are useful as modulators of ATP-Binding Cassette ("ABC") transporters of fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR").
摘要翻译： 本发明的药学上可接受的组合物可用作其片段的ATP结合盒（“ABC”）转运体的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。
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公开(公告)号：EP2365972B1
公开(公告)日：2014-12-17
申请号：EP08876364.4
申请日：2008-11-12
发明人： RUAH, Sara, S., Hadida , GROOTENHUIS, Peter, D., J. , VAN GOOR, Fredrick , MILLER, Mark, T. , MCCARTNEY, Jason , ZHOU, Jinglan , BEAR, Brian , NUMA, Mehdi, Michel, Djamel
IPC分类号： C07D405/12 , A61K31/404 , A61P3/00 , A61P25/00
CPC分类号： C07D405/12 , C07D209/08 , C07D209/12 , C07D209/18 , C07D405/14 , C07D487/04
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公开(公告)号：EP2365972A1
公开(公告)日：2011-09-21
申请号：EP08876364.4
申请日：2008-11-12
发明人： RUAH, Sara, Hadida, S. , GROOTENHUIS, Peter, D., J. , VAN GOOR, Fredrick , MILLER, Mark, T. , MCCARTNEY, Jason , ZHOU, Jinglan , BEAR, Brian , NUMA, Mehdi, Michel, Djamel
IPC分类号： C07D405/12 , A61K31/404 , A61P3/00 , A61P25/00
CPC分类号： C07D405/12 , C07D209/08 , C07D209/12 , C07D209/18 , C07D405/14 , C07D487/04
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：EP1945632A1
公开(公告)日：2008-07-23
申请号：EP06837028.7
申请日：2006-11-08
发明人： HADIDA RUAH, Sara , HAMILTON, Matthew , MILLER, Mark , GROOTENHUIS, Peter, D., J. , BEAR, Brian , MCCARTHY, Jason , ZHOU, Jinglan
IPC分类号： C07D405/12 , C07D405/14 , C07D213/75 , A61K31/5585 , A61K31/4418 , A61P11/00
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Pharmaceutically acceptable compositions of the present invention are useful as modulators of ATP-Binding Cassette ("ABC") transporters of fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR").
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5.发明授权Modulators of ATP-binding cassette transporters 有权Modulatoren von Transportern der ATP bindenden Kassette
公开(公告)号：EP1773816B1
公开(公告)日：2015-01-07
申请号：EP05791060.6
申请日：2005-06-24
发明人： HADIDA RUAH, Sarah, S. , HAZLEWOOD, Anna, R. , GROOTENHUIS, Peter, D., J. , VAN GOOR, Fredrick, F. , SINGH, Ashvani, K. , ZHOU, Jinglan , MCCARTNEY, Jason
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
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公开(公告)号：EP2217572B1
公开(公告)日：2013-11-06
申请号：EP08849242.6
申请日：2008-11-14
IPC分类号： C07D217/22 , A61K31/472 , A61K31/4725 , A61P11/00 , C07D401/04 , C07D405/12 , C07D405/14
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D217/22 , C07D401/04 , C07D405/12 , C07D405/14
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公开(公告)号：EP1865949B1
公开(公告)日：2012-11-14
申请号：EP06737945.3
申请日：2006-03-13
IPC分类号： C07D209/18 , C07D401/12 , C07D403/12 , A61P1/18 , A61P11/00 , A61P3/10 , A61P3/00 , A61P9/00 , A61P11/06 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P35/00 , A61P43/00
CPC分类号： C07D209/20 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , C07D209/18 , C07D401/12 , C07D403/12
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8.发明公开NAPHTHYRIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MUSCARINIC RECEPTORS 审中-公开萘啶衍生物和它们作为毒蕈碱受体的调节剂的用途
公开(公告)号：EP1709045A1
公开(公告)日：2006-10-11
申请号：EP04817977.4
申请日：2004-12-07
发明人： GROOTENHUIS, Peter, D., J. , GARCIA-GUZMAN BLANCO, Miguel , MAKINGS, Lewis, R. , LONDO, Philip, Martin
IPC分类号： C07D471/04 , A61K31/4745 , A61P25/00
CPC分类号： C07D471/04
摘要： A compound of formula (I) wherein: Ring A is aryl or heteroaryl; one of V, W, Y or Z is nitrogen and the other of V, W, Y and Z are -C(R5)-; modulate muscarinic receptors and are useful for treating muscarinic receptor mediated diseases.
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公开(公告)号：EP2217572A1
公开(公告)日：2010-08-18
申请号：EP08849242.6
申请日：2008-11-14
IPC分类号： C07D217/22 , A61K31/472 , A61K31/4725 , A61P11/00 , C07D401/04 , C07D405/12 , C07D405/14
CPC分类号： A61K31/4725 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D217/22 , C07D401/04 , C07D405/12 , C07D405/14
摘要： Compounds of the present invention, of formula (I) and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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10.发明授权THIAZOLES AND OXAZOLES USEFUL AS MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 有权噻唑UDN恶唑AS ATP结合盒转运调节剂的
公开(公告)号：EP1682127B1
公开(公告)日：2009-07-29
申请号：EP04811321.1
申请日：2004-11-15
IPC分类号： A61K31/42 , A61K31/422 , A61K31/426 , A61K31/427 , C07D277/56 , C07D417/12 , C07D417/04 , C07D417/06 , C07D263/34
CPC分类号： C07D263/34 , A61K31/42 , A61K31/422 , A61K31/426 , A61K31/427 , C07D277/56 , C07D417/04 , C07D417/06 , C07D417/12
摘要： The present invention relates to modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator ('CFTR'), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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