发明公开
EP2217591A1 SOME 2-PYRAZINONE DERIVATIVES AND THEIR USE AS INHIBITORS OF NEUTROPHILE ELASTASE
审中-公开
2 PYRAZINONDERIVATE及其作为抑制剂中性粒细胞弹性
- 专利标题： SOME 2-PYRAZINONE DERIVATIVES AND THEIR USE AS INHIBITORS OF NEUTROPHILE ELASTASE
- 专利标题（中）： 2 PYRAZINONDERIVATE及其作为抑制剂中性粒细胞弹性
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申请号： EP08847756.7申请日： 2008-11-05
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公开(公告)号： EP2217591A1公开(公告)日： 2010-08-18
- 发明人: AINGE, Debra , CHAPMAN, David , LINDSJÖ, Martin , LÖNN, Hans , LUNDKVIST, Michael , MUNCK AF ROSENSCHÖLD, Magnus , NIKITIDIS, Antonios , PAVEY, John
- 申请人： AstraZeneca AB
- 申请人地址： 151 85 Södertälje SE
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： 151 85 Södertälje SE
- 代理机构： Nelson, Michael Andrew
- 优先权： US985713P 20071106
- 国际公布： WO2009061271 20090514
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; A61K31/497 ; A61P1/04 ; A61P11/00 ; A61P19/00 ; C07D401/14
摘要：
The invention provides certain novel 6-heteroaryl-5-methyl-3- oxo-4- [3 (trif luoromethyl) phenyl] -3,4-dihydropyrazine-2- carboxamide derivatives and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitord of human neutrophil elastase.
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