发明公开
EP2223921A1 2-Thiophen-2-yl-oxazole, 2-Thiophen-2-yl-thiazole and 2-Thiophen-2-yl-1H-imidazole derivatives as antiviral agents
有权
2-噻吩-2-基 - 恶唑-2-噻吩-2-基 - 噻唑-2-磺基-2-基-1H-咪唑衍生物抗病毒剂Wirkstoffe
- 专利标题： 2-Thiophen-2-yl-oxazole, 2-Thiophen-2-yl-thiazole and 2-Thiophen-2-yl-1H-imidazole derivatives as antiviral agents
- 专利标题（中）： 2-噻吩-2-基 - 恶唑-2-噻吩-2-基 - 噻唑-2-磺基-2-基-1H-咪唑衍生物抗病毒剂Wirkstoffe
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申请号： EP10003376.0申请日： 2006-01-24
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公开(公告)号： EP2223921A1公开(公告)日： 2010-09-01
- 发明人: Nan, Fajun , Zuo, Jianping , Wang, Wenlong , Wang, Guifeng , Chen, Haijun , He, Peilan
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 申请人地址： 555 Zu Chong Zhi Road Zhangjlang Hi-Tech Park Pudong New District Shanghai 201023 CN
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人地址： 555 Zu Chong Zhi Road Zhangjlang Hi-Tech Park Pudong New District Shanghai 201023 CN
- 代理机构： Flaccus, Rolf-Dieter
- 优先权： CN200510024468 20050318
- 主分类号： C07D417/04
- IPC分类号： C07D417/04 ; C07D417/14 ; C07D413/04 ; C07D413/14 ; C07D403/04 ; C07D405/04 ; C07D407/04 ; C07D409/04 ; A61K31/41 ; A61K31/42 ; A61K31/425
摘要：
The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.
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