发明授权
EP2225210B1 Dual-acting benzoimidazole derivative and their use as antihypertensive agents
有权
双重作用的苯并咪唑衍生物及其作为抗高血压药物的使用
- 专利标题： Dual-acting benzoimidazole derivative and their use as antihypertensive agents
- 专利标题（中）： 双重作用的苯并咪唑衍生物及其作为抗高血压药物的使用
-
申请号： EP08859870.1申请日： 2008-12-08
-
公开(公告)号： EP2225210B1公开(公告)日： 2012-04-25
- 发明人: CHOI, Seok-ki , FATHEREE, Paul R. , MCKINNELL, Robert Murray , OLSON, Brooke
- 申请人： Theravance, Inc.
- 申请人地址： 901 Gateway Boulevard South San Francisco, CA 94080 US
- 专利权人： Theravance, Inc.
- 当前专利权人： Theravance, Inc.
- 当前专利权人地址： 901 Gateway Boulevard South San Francisco, CA 94080 US
- 代理机构： Scott, Susan Margaret
- 优先权： US7129 20071211
- 国际公布： WO2009076288 20090618
- 主分类号： C07D235/08
- IPC分类号： C07D235/08 ; C07D235/26 ; C07D403/10 ; A61K31/4184 ; A61P9/00
摘要：
The invention relates to compounds having the formula: (I) wherein Ar, r, n, X, R2, R2', R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
公开/授权文献
信息查询
