发明公开
EP2226325A1 PROCESS FOR PRODUCTION OF 4-(SUBSTITUTED PHENYL)HEXAHYDROPYRIDOÝ2,1-C¨Ý1,4¨OXAZIN-6-ONE
审中-公开
生产4-（取代苯基）六氢吡啶并[2,1-c] 1,4-氧氮杂-6-酮的方法
- 专利标题： PROCESS FOR PRODUCTION OF 4-(SUBSTITUTED PHENYL)HEXAHYDROPYRIDOÝ2,1-C¨Ý1,4¨OXAZIN-6-ONE
- 专利标题（中）： 生产4-（取代苯基）六氢吡啶并[2,1-c] 1,4-氧氮杂-6-酮的方法
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申请号： EP08863919.0申请日： 2008-12-25
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公开(公告)号： EP2226325A1公开(公告)日： 2010-09-08
- 发明人: KAYANO, Akio , NAGAI, Mitsuo , HOSHINO, Yorihisa , WAKASUGI, Kazunori , MATSUDA, Masaaki , KAMADA, Atsushi , ISOMURA, Minetaka , NISHIKAWA, Yoshihiro , YOSHIKAWA, Seiji , SHIMMYO, Daisuke , DOI, Eriko , KANEKO, Toshihiko
- 申请人： Eisai R&D Management Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112-8088 JP
- 专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112-8088 JP
- 代理机构： HOFFMANN EITLE
- 优先权： US16796 20071226
- 国际公布： WO2009081959 20090702
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; C07D265/30
摘要：
4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one represented by formula (I) or a salt thereof is useful as an intermediate for the production of a bicyclic cinnamide compound which is an Aβ production inhibitor. 4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one or the salt thereof can be produced in an industrially advantageous manner by subjecting a compound represented by formula (II) or a salt thereof to an intramolecular condensation reaction.
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