-
公开(公告)号：EP2048143A1
公开(公告)日：2009-04-15
申请号：EP07791337.4
申请日：2007-07-26
发明人： KIMURA, Teiji , KAWANO, Koki , KITAZAWA, Noritaka , SATO, Nobuaki , KANEKO, Toshihiko , ITO, Koichi , TAKAISHI, Mamoru , KUSHIDA, Ikuo
IPC分类号： C07D401/10 , A61K31/454 , A61K31/661 , A61P25/28 , A61P43/00 , C07F9/6558 , C07F9/6561
CPC分类号： C07D401/10 , C07F9/65583 , C07F9/6561
摘要： Disclosed is an optimal prodrug of a cinnamide compound represented by Formula (I) below.
In the formula, R a and R b respectively represent a C1-6 alkyl group or the like; X a represents a methoxy group or a fluorine atom; Y represents a phosphono group or the like; and A represents a cyclic lactam derivative.摘要翻译： 公开了由下式（I）表示的肉桂酰胺化合物的最佳前药。 在该式中，Ra和Rb分别表示C1-6烷基等; Xa代表甲氧基或氟原子; Y代表膦酰基等; A表示环内酰胺衍生物。
-
公开(公告)号：EP1950211A1
公开(公告)日：2008-07-30
申请号：EP06832861.6
申请日：2006-11-17
发明人： SHIMOMURA, Naoyuki , SATO, Nobuaki , KANEKO, Toshihiko , TAKAISHI, Mamoru , WAKASUGI, Kazunori , YOSHIKAWA, Seiji , NISHIKAWA, Yoshihiro , NAKAMURA, Taiju , FUKUYAMA, Tohru
IPC分类号： C07D401/10 , A61K31/4439 , A61P25/28 , A61P43/00 , C07D211/76 , C07D211/78 , C07D233/61
CPC分类号： C07D401/10
摘要： A compound (8) represented by the formula: (8)
wherein R 1 represents a 6- to 14-membered aromatic hydrocarbon ring group which may have a substituent; and n represents 0 to 2, can be produced with good efficiency by reacting a compound (3) represented by the formula: (3)
wherein R 1 and n are as defined above; and Q represents a single bond or -CH(Y)- where Y represents a hydrogen atom or a C1-6 alkyl group] with 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in the presence of a base.摘要翻译： 由式（8）表示的化合物（8）其中R1表示可以具有取代基的6至14元芳族烃环基团; （3）表示的化合物（3）（其中R1和n如上所定义）反应，可以高效地制备n为0至2的化合物。 和Q代表单键或-CH（Y） - ，其中Y代表氢原子或C1-6烷基]与3-甲氧基-4-（4-甲基-1H-咪唑-1-基）苯甲醛在 基地的存在。
-
公开(公告)号：EP2318416B1
公开(公告)日：2013-09-04
申请号：EP09788008.2
申请日：2009-07-24
IPC分类号： C07D513/10 , A61K31/547 , A61P25/28
CPC分类号： C07D513/10
-
公开(公告)号：EP2125829B1
公开(公告)日：2013-01-16
申请号：EP08721307.0
申请日：2008-02-27
发明人： KIMURA, Teiji , KAWANO, Koki , DOI, Eriko , KITAZAWA, Noritaka , TAKAISHI, Mamoru , ITO, Koichi , KANEKO, Toshihiko , SASAKI, Takeo , SATO, Nobuaki , MIYAGAWA, Takehiko , HAGIWARA, Hiroaki
IPC分类号： C07D498/04 , A61K31/5375 , A61P25/00
CPC分类号： C07D498/04
-
公开(公告)号：EP2241567A1
公开(公告)日：2010-10-20
申请号：EP09710649.6
申请日：2009-02-09
发明人： OZAKI, Fumihiro , SOEJIMA, Motohiro , ISHIDA, Tasuku , NORIMINE, Yoshihiko , KURUSU, Nobuyuki , DOI, Eriko , KANEKO, Toshihiko , HASEGAWA, Daiju , KOBAYASHI, Kiyoaki , YAMAMOTO, Noboru
IPC分类号： C07D451/06 , A61K31/439 , A61K31/46 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/55 , A61P3/12 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P29/02 , A61P43/00 , C07D451/14 , C07D519/00
CPC分类号： C07D451/06 , C07D451/02 , C07D451/04 , C07D519/00
摘要： Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various kinds of neuralgia, neuropathy, epilepsy, insomnia, premature ejaculation and the like.
wherein Q represents ethylene, etc., R 1 , R 2 and R 3 represent hydrogen, etc., X 1 represents C 1-6 alkylene, etc., X 2 represents C 1-6 alkylene, etc., A 1 represents a 5- to 6-membered heterocyclic group, etc., and A 2 represents C 6-14 aryl, etc.摘要翻译： 由式（I）表示的化合物及其药学上可接受的盐具有优异的钠通道抑制作用，可用作各种神经痛，神经病，癫痫，失眠，早泄等的治疗剂和止痛剂。 其中Q表示乙烯等，R 1，R 2和R 3表示氢等，X 1表示C 1-6亚烷基等，X 2表示C 1-6亚烷基等，A 1表示 5-至6-元杂环基等，A 2表示C 6-14芳基等
-
6.发明公开PROCESS FOR PRODUCTION OF 4-(SUBSTITUTED PHENYL)HEXAHYDROPYRIDOÝ2,1-C¨Ý1,4¨OXAZIN-6-ONE 审中-公开生产4-（取代苯基）六氢吡啶并[2,1-c] 1,4-氧氮杂-6-酮的方法
公开(公告)号：EP2226325A1
公开(公告)日：2010-09-08
申请号：EP08863919.0
申请日：2008-12-25
发明人： KAYANO, Akio , NAGAI, Mitsuo , HOSHINO, Yorihisa , WAKASUGI, Kazunori , MATSUDA, Masaaki , KAMADA, Atsushi , ISOMURA, Minetaka , NISHIKAWA, Yoshihiro , YOSHIKAWA, Seiji , SHIMMYO, Daisuke , DOI, Eriko , KANEKO, Toshihiko
IPC分类号： C07D498/04 , C07D265/30
CPC分类号： C07D265/30 , C07D498/04
摘要： 4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one represented by formula (I) or a salt thereof is useful as an intermediate for the production of a bicyclic cinnamide compound which is an Aβ production inhibitor. 4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one or the salt thereof can be produced in an industrially advantageous manner by subjecting a compound represented by formula (II) or a salt thereof to an intramolecular condensation reaction.
摘要翻译： 由式（I）表示的4-（取代苯基）六氢吡啶并[2,1-c] [1,4]恶嗪-6-酮或其盐可用作生产双环肉桂酰胺化合物的中间体， Aβ产生抑制剂。 可以工业上有利的方式制备4-（取代的苯基）六氢吡啶并[2,1-c] [1,4]恶嗪-6-酮或其盐，其中通过使由式（II）表示的化合物或其盐 进行分子内缩合反应。
-
公开(公告)号：EP2019094A1
公开(公告)日：2009-01-28
申请号：EP07743623.6
申请日：2007-05-18
发明人： KIMURA, Teiji , KAWANO, Koki , DOI, Eriko , KITAZAWA,Noritaka , MIYAGAWA, Takehiko , SATO, Nobuaki , KANEKO, Toshihiko , SHIN, Kogyoku , ITO, Koichi , TAKAISHI, Mamoru , SASAKI, Takeo , HAGIWARA, Hiroaki
IPC分类号： C07D249/08 , A61K31/4196 , A61K31/437 , A61K31/4375 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61P25/28 , A61P43/00 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/14 , C07D471/04
CPC分类号： C07D249/08 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/14 , C07D471/04
摘要： Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product.
(In the formula, Ar 1 represents a triazolyl group or the like which may be substituted with a C 1-6 alkyl group or the like; Ar 2 represents a phenyl group or the like which may be substituted with a C 1-6 alkoxy group or the like; X 1 represents -CR 3 =CR 4 - (wherein R 3 and R 4 respectively represent a C 1-6 alkyl group or the like); and R 1 and R 2 respectively represent a C 1-6 alkyl group or the like.)摘要翻译： 公开了由下式（I）表示的化合物或其药理学上可接受的盐。 还公开了该化合物或盐作为药物产品的用途。 （式中，Ar1表示可以被C1-6烷基等取代的三唑基等; Ar2表示可以被C1-6烷氧基等取代的苯基等 ; X 1表示-CR 3 = CR 4 - （其中R 3和R 4分别表示C 1-6烷基等）;并且R 1和R 2分别表示C 1-6烷基等。
-
8.发明授权
公开(公告)号：EP1254895B1
公开(公告)日：2007-05-23
申请号：EP01901413.3
申请日：2001-01-18
发明人： YAMAMOTO, Noboru , SUZUKI, Yuichi , KIMURA, Manami , NIIDOME, Tetsuhiro , IIMURA, Yoichi , TERAMOTO, Tetsuyuki , KANEDA, Yoshihisa , KANEKO, Toshihiko , KURUSU, Nobuyuki , SHINMYO, Daisuke , YOSHIKAWA, Yukie , HATAKEYAMA, Shinji
IPC分类号： C07D333/26 , A61K31/495 , A61K31/381 , A61P9/10
CPC分类号： C07D207/337 , C07D207/09 , C07D207/14 , C07D207/16 , C07D209/14 , C07D209/42 , C07D211/22 , C07D211/26 , C07D211/32 , C07D211/34 , C07D211/46 , C07D211/58 , C07D211/64 , C07D213/36 , C07D213/57 , C07D213/74 , C07D215/06 , C07D215/12 , C07D215/227 , C07D215/38 , C07D217/04 , C07D217/22 , C07D235/14 , C07D235/30 , C07D241/04 , C07D243/08 , C07D261/08 , C07D263/20 , C07D263/32 , C07D263/58 , C07D271/06 , C07D277/28 , C07D277/42 , C07D277/82 , C07D295/145 , C07D295/185 , C07D295/192 , C07D295/215 , C07D307/52 , C07D307/54 , C07D307/81 , C07D319/20 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/60 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D405/06 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D471/10 , C07D487/08
摘要： Novel compounds exhibiting excellent calcium antagonism, particularly neuroselective calcium antagonism, namely, compounds of the general formula (I), salts of the same, or hydrates of both wherein Ar is a group derived from an optionally substituted 5- to 14-membered aromatic ring, or the like; the ring A is one member selected from among piperazine, homopiperazine, piperidine and so on; the ring B is an optionally substituted C3-14 hydrocarbon ring or the like; E is a single bond, -CO-, or the like; X is a single bond, oxygen, or the like; R1 is hydrogen, halogeno, hydroxyl, or the like; and D?1, D2, W1 and W2¿ are each independently a single bond or optionally substituted C¿1-6? alkylene.
-
公开(公告)号：EP2233474B1
公开(公告)日：2015-08-05
申请号：EP09701914.5
申请日：2009-01-16
发明人： SUZUKI, Yuichi , MOTOKI, Takafumi , KANEKO, Toshihiko , TAKAISHI, Mamoru , ISHIDA, Tasuku , TAKEDA, Kunitoshi , KITA, Yoichi , YAMAMOTO, Noboru , KHAN, Afzal , DIMOPOULOS, Paschalis
IPC分类号： C07D279/08 , A61K31/4439 , A61K31/5415 , A61K31/542 , A61P25/28 , A61P43/00 , C07D417/10 , C07D417/12 , C07D513/04 , C07D417/14
CPC分类号： A61K31/542 , C07D279/08 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
-
公开(公告)号：EP1992618A1
公开(公告)日：2008-11-19
申请号：EP07738023.6
申请日：2007-03-08
发明人： KIMURA, Teiji , KITAZAWA, Noritaka , KANEKO, Toshihiko , SATO, Nobuaki , KAWANO, Koki , ITO, Koichi , DOI, Eriko , TAKAISHI, Mamoru , SASAKI, Takeo , DOKO, Takashi , MIYAGAWA, Takehiko , HAGIWARA, Hiroaki
IPC分类号： C07D233/64 , A61K31/4178 , A61K31/4196 , A61K31/437 , A61K31/4985 , A61K31/5383 , A61P25/28 , A61P43/00 , C07D233/90 , C07D403/10 , C07D405/06 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D233/64
摘要： Disclosed is a compound represented by the formula (I):
or a pharmacologically acceptable salt thereof, wherein Ar 1 represents an imidazolyl group which may be substituted by a C1-6 alkyl group, or the like, Ar 2 represents a phenyl group which may be substituted by a C1-6 alkoxy group, or the like, X 1 represents a double bond or the like, and Het represents an imidazolyl group which may be substituted by a C1-6 alkyl group, or the like. The compound or the salt is effective as a therapeutic or prophylactic agent for a disease associated with Aβ.摘要翻译： 公开了由式（I）表示的化合物或其药理学上可接受的盐，其中Ar 1表示可被C 1-6烷基取代的咪唑基等，Ar 2表示可以 被C 1-6烷氧基等取代，X 1表示双键等，Het表示可被C 1-6烷基取代的咪唑基等。 该化合物或盐作为与A 2相关的疾病的治疗或预防剂是有效的。
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.033 秒)
