发明公开
EP2231650A1 ISOXAZOLE DERIVATIVES AS MODULATORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
审中-公开
异恶唑的11-β-羟基TYPE 1调节剂
- 专利标题： ISOXAZOLE DERIVATIVES AS MODULATORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
- 专利标题（中）： 异恶唑的11-β-羟基TYPE 1调节剂
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申请号： EP09702264.4申请日： 2009-01-16
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公开(公告)号： EP2231650A1公开(公告)日： 2010-09-29
- 发明人: BYSTRÖM, Styrbjörn , HARALDSSON, Martin , JOHANSSON, Lars , TEJBRANT, Jan
- 申请人： Biovitrum AB (publ)
- 申请人地址： 112 76 Stockholm SE
- 专利权人： Biovitrum AB (publ)
- 当前专利权人： Biovitrum AB (publ)
- 当前专利权人地址： 112 76 Stockholm SE
- 代理机构： Höglund, Lars
- 优先权： SE0800108 20080117
- 国际公布： WO2009090239 20090723
- 主分类号： C07D413/06
- IPC分类号： C07D413/06 ; A61K31/454 ; A61P27/00
摘要：
The present invention relates to novel isoxazole compounds of formula (I), and pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides thereof, which are modulators of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the preparation of a medicament for the treatment of glaucoma.
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