发明公开
EP2235003A1 DERIVES D'INDOLE 2-CARBOXAMIDES ET D'AZAINDOLE 2-CARBOXAMIDES SUBSTITUES PAR UN GROUPE SILANYLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
有权
BY硅烷基衍生物的取代的吲哚-2-羧酰胺和氮杂吲哚-2-羧酰胺，生产和治疗用途
- 专利标题： DERIVES D'INDOLE 2-CARBOXAMIDES ET D'AZAINDOLE 2-CARBOXAMIDES SUBSTITUES PAR UN GROUPE SILANYLE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
- 专利标题（英）： Derivatives of indole 2-carboxamides and azaindole 2-carboxamides substituted by a silanyle group, preparation thereof and therapeutic use thereof
- 专利标题（中）： BY硅烷基衍生物的取代的吲哚-2-羧酰胺和氮杂吲哚-2-羧酰胺，生产和治疗用途
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申请号： EP09718226.5申请日： 2009-01-20
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公开(公告)号： EP2235003A1公开(公告)日： 2010-10-06
- 发明人: DUBOIS, Laurent , EVANNO, Yannick , MALANDA, André
- 申请人： Sanofi-Aventis
- 申请人地址： 174, Avenue de France 75013 Paris FR
- 专利权人： Sanofi-Aventis
- 当前专利权人： Sanofi-Aventis
- 当前专利权人地址： 174, Avenue de France 75013 Paris FR
- 代理机构： Rauline, Mathilde
- 优先权： FR0800343 20080123
- 国际公布： WO2009109710 20090911
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07F7/08 ; C07F7/10 ; C07F7/12 ; A61K31/695 ; A61K31/4439 ; A61P25/00 ; A61P3/00 ; A61P13/00 ; A61P15/00
摘要：
The invention relates to compounds of the general formula (I) in which: G
1 , G
2 , G
3 et G
4 are independent from one another, a C-X group or a nitrogen atom; one of G
1 , G
2 , G
3 and G
4 and at most one of G
1 , G
2 , G
3 and G
4 is a C-X group In which X is a -Si(X
1 )(X
2 )(X
3 ) group; n is 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; Z1, Z2, Z3, Z4 are independent from one another, a nitrogen atom or a C(R
6 ) group, at least one being a nitrogen atom and at least one being a C(R
6 ) group; Z is cyclic amino or acyclic amino; said compounds can be in the state of a base or an addition salt to an acid, as well as in the hydrate or solvate state. The invention also relates to a method for preparing the same and to the therapeutic use thereof.
1 , G
2 , G
3 et G
4 are independent from one another, a C-X group or a nitrogen atom; one of G
1 , G
2 , G
3 and G
4 and at most one of G
1 , G
2 , G
3 and G
4 is a C-X group In which X is a -Si(X
1 )(X
2 )(X
3 ) group; n is 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; Z1, Z2, Z3, Z4 are independent from one another, a nitrogen atom or a C(R
6 ) group, at least one being a nitrogen atom and at least one being a C(R
6 ) group; Z is cyclic amino or acyclic amino; said compounds can be in the state of a base or an addition salt to an acid, as well as in the hydrate or solvate state. The invention also relates to a method for preparing the same and to the therapeutic use thereof.
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