发明公开
- 专利标题: DISPLAY VECTORS AND METHODS AND USES THEREOF
- 专利标题(中): 展示载体和方法和用途
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申请号: EP09700624.1申请日: 2009-01-09
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公开(公告)号: EP2235181A1公开(公告)日: 2010-10-06
- 发明人: ENZELBERGER, Markus , YODER, Stephen , NEUN, Rüdiger , THIEL, Philippe , PETERS, Solveig
- 申请人: MorphoSys AG
- 申请人地址: Lena-Christ-Strasse 48 82152 Planegg-Martinsried DE
- 专利权人: MorphoSys AG
- 当前专利权人: MorphoSys AG
- 当前专利权人地址: Lena-Christ-Strasse 48 82152 Planegg-Martinsried DE
- 代理机构: Hutter, Bernd
- 优先权: US20456 20080111
- 国际公布: WO2009087230 20090716
- 主分类号: C12N15/79
- IPC分类号: C12N15/79
摘要:
The present invention relates, in one aspect, to a vector comprising (a) a first polynucleotide capable of encoding a first (poly)peptide comprising at least one cysteine residue, and (b) a second polynucleotide capable of encoding a second (poly)peptide which is a cell surface anchor comprising at least one cysteine residue, wherein the vector is operable in a eukaryotic host cell to express and to cause or allow the attachment of said first (poly)peptide to said second (poly)peptide by formation of a disulfide bond between said cysteine residues comprised within said first (polypeptide and said second (poly)peptide, respectively, wherein said first (poly)peptide is exhibited at the surface of a eukaryotic host cell.
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