公开(公告)号：EP2235181A1

公开(公告)日：2010-10-06

申请号：EP09700624.1

申请日：2009-01-09

申请人： MorphoSys AG

发明人： ENZELBERGER, Markus ,  YODER, Stephen ,  NEUN, Rüdiger ,  THIEL, Philippe ,  PETERS, Solveig

IPC分类号： C12N15/79

CPC分类号： C12N15/1037

摘要： The present invention relates, in one aspect, to a vector comprising (a) a first polynucleotide capable of encoding a first (poly)peptide comprising at least one cysteine residue, and (b) a second polynucleotide capable of encoding a second (poly)peptide which is a cell surface anchor comprising at least one cysteine residue, wherein the vector is operable in a eukaryotic host cell to express and to cause or allow the attachment of said first (poly)peptide to said second (poly)peptide by formation of a disulfide bond between said cysteine residues comprised within said first (polypeptide and said second (poly)peptide, respectively, wherein said first (poly)peptide is exhibited at the surface of a eukaryotic host cell.