发明公开
- 专利标题: Polymer conjugates of mutated neublastin
- 专利标题(中): 突变的神经胚素的聚合物缀合物
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申请号: EP10173737.7申请日: 2004-02-02
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公开(公告)号: EP2246362A2公开(公告)日: 2010-11-03
- 发明人: Sah, Dinah, Wen-Yee , Pepinsky, R. Blake , Boriack-Sjodin, Paula Ann , Miller, Stephan S. , Rossomando, Anthony , Silvian, Laura
- 申请人: Biogen Idec MA Inc.
- 申请人地址: 14 Cambridge Center Cambridge, Massachusetts 02142 US
- 专利权人: Biogen Idec MA Inc.
- 当前专利权人: Biogen Idec MA Inc.
- 当前专利权人地址: 14 Cambridge Center Cambridge, Massachusetts 02142 US
- 代理机构: Pohlman, Sandra M.
- 优先权: US356264 20030131
- 主分类号: C07K14/475
- IPC分类号: C07K14/475 ; A61K47/48
摘要:
A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.
公开/授权文献
- EP2246362B1 Polymer conjugates of mutated neublastin 公开/授权日:2013-12-18
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