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公开(公告)号:EP2246362B1
公开(公告)日:2013-12-18
申请号:EP10173737.7
申请日:2004-02-02
申请人: Biogen Idec MA Inc.
发明人: Sah, Dinah, Wen-Yee , Pepinsky, R. Blake , Boriack-Sjodin, Paula Ann , Miller, Stephan S. , Rossomando, Anthony , Silvian, Laura
IPC分类号: C07K14/475 , A61K47/48
CPC分类号: C07K14/4756 , A61K38/00 , A61K39/00 , A61K47/60 , C07K14/475 , C07K2319/00
摘要: A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.
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公开(公告)号:EP2246362A2
公开(公告)日:2010-11-03
申请号:EP10173737.7
申请日:2004-02-02
申请人: Biogen Idec MA Inc.
发明人: Sah, Dinah, Wen-Yee , Pepinsky, R. Blake , Boriack-Sjodin, Paula Ann , Miller, Stephan S. , Rossomando, Anthony , Silvian, Laura
IPC分类号: C07K14/475 , A61K47/48
CPC分类号: C07K14/4756 , A61K38/00 , A61K39/00 , A61K47/60 , C07K14/475 , C07K2319/00
摘要: A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.
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公开(公告)号:EP2301960A2
公开(公告)日:2011-03-30
申请号:EP10181704.7
申请日:2004-02-02
申请人: Biogen Idec MA Inc.
发明人: Sah, Dinah Wen-Yee , Pepinsky, R. Blake , Boriack-Sjodin, Paula Ann , Miller, Stephan S. , Rossomando, Anthony , Silvian, Laura
IPC分类号: C07K14/475 , A61K47/48
CPC分类号: C07K14/4756 , A61K38/00 , A61K39/00 , A61K47/60 , C07K14/475 , C07K2319/00
摘要: A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.
摘要翻译: 公开了包含与聚合物偶联的突变的新伯斯加蛋白多肽的二聚体。 这样的二聚体表现出延长的生物利用度,并且在优选的实施方案中,相对于野生型形式的新斯霉素具有延长的生物活性。
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公开(公告)号:EP2301960A3
公开(公告)日:2011-08-03
申请号:EP10181704.7
申请日:2004-02-02
申请人: Biogen Idec MA Inc.
发明人: Sah, Dinah Wen-Yee , Pepinsky, R. Blake , Boriack-Sjodin, Paula Ann , Miller, Stephan S. , Rossomando, Anthony , Silvian, Laura
IPC分类号: C07K14/475 , A61K47/48
CPC分类号: C07K14/4756 , A61K38/00 , A61K39/00 , A61K47/60 , C07K14/475 , C07K2319/00
摘要: A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.
摘要翻译: 公开了包含与聚合物偶联的突变的神经胚素多肽的二聚体。 此类二聚体展现出延长的生物利用度,并且在优选的实施方案中,相对于野生型神经胚素的生物活性延长。
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公开(公告)号:EP2246362A3
公开(公告)日:2011-02-23
申请号:EP10173737.7
申请日:2004-02-02
申请人: Biogen Idec MA Inc.
发明人: Sah, Dinah, Wen-Yee , Pepinsky, R. Blake , Boriack-Sjodin, Paula Ann , Miller, Stephan S. , Rossomando, Anthony , Silvian, Laura
IPC分类号: C07K14/475 , A61K47/48
CPC分类号: C07K14/4756 , A61K38/00 , A61K39/00 , A61K47/60 , C07K14/475 , C07K2319/00
摘要: A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.
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