发明公开
EP2246420A1 L-CYSTEINE-PRODUCING BACTERIUM, AND METHOD FOR PRODUCTION OF L-CYSTEINE
有权
L-CYSTEIN-PRODUZIERENDES BAKTERIUM UND VERFAHREN ZUR HERSTELLUNG VON L-CYSTEIN
- 专利标题： L-CYSTEINE-PRODUCING BACTERIUM, AND METHOD FOR PRODUCTION OF L-CYSTEINE
- 专利标题（中）： L-CYSTEIN-PRODUZIERENDES BAKTERIUM UND VERFAHREN ZUR HERSTELLUNG VON L-CYSTEIN
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申请号： EP09713597.4申请日： 2009-02-20
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公开(公告)号： EP2246420A1公开(公告)日： 2010-11-03
- 发明人: NONAKA, Gen , TAKAGI, Hiroshi , OHTSU, Iwao
- 申请人： Ajinomoto Co., Inc. , National University Corporation Nara Institute of Science and Technology
- 申请人地址： 15-1, Kyobashi 1-chome Chuo-ku Tokyo 104-8315 JP
- 专利权人： Ajinomoto Co., Inc.,National University Corporation Nara Institute of Science and Technology
- 当前专利权人： Ajinomoto Co., Inc.,National University Corporation Nara Institute of Science and Technology
- 当前专利权人地址： 15-1, Kyobashi 1-chome Chuo-ku Tokyo 104-8315 JP
- 代理机构： Strehl Schübel-Hopf & Partner
- 优先权： JP2008040167 20080221
- 国际公布： WO2009104731 20090827
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; C12N1/21 ; C12N15/09 ; C12P13/12
摘要：
L-Cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and has been modified so that the activity of a protein encoded by a tolC gene, for example, a protein defined in the following (A) or (B) is increased, in a medium and collecting L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof from the medium:
(A) a protein comprising the amino acid sequence of SEQ ID NO: 2,
(B) a protein comprising the amino acid sequence of SEQ ID NO: 2 including substitutions, deletions, insertions or additions of one or several amino acid residues, increase of which activity in the bacterium improves L-cysteine-producing ability of the bacterium.
(A) a protein comprising the amino acid sequence of SEQ ID NO: 2,
(B) a protein comprising the amino acid sequence of SEQ ID NO: 2 including substitutions, deletions, insertions or additions of one or several amino acid residues, increase of which activity in the bacterium improves L-cysteine-producing ability of the bacterium.
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