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    L-CYSTEINE-PRODUCING BACTERIUM, AND METHOD FOR PRODUCTION OF L-CYSTEINE
    2.
    发明公开
    L-CYSTEINE-PRODUCING BACTERIUM, AND METHOD FOR PRODUCTION OF L-CYSTEINE 有权
    L-CYSTEIN-PRODUZIERENDES BAKTERIUM UND VERFAHREN ZUR HERSTELLUNG VON L-CYSTEIN

    公开(公告)号：EP2246420A1

    公开(公告)日：2010-11-03

    申请号：EP09713597.4

    申请日：2009-02-20

    申请人： Ajinomoto Co., Inc. ,  National University Corporation Nara Institute of Science and Technology

    发明人： NONAKA, Gen ,  TAKAGI, Hiroshi ,  OHTSU, Iwao

    IPC分类号： C12N15/00 ,  C12N1/21 ,  C12N15/09 ,  C12P13/12

    CPC分类号： C12N1/20 ,  C07K14/245 ,  C12P13/12

    摘要： L-Cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and has been modified so that the activity of a protein encoded by a tolC gene, for example, a protein defined in the following (A) or (B) is increased, in a medium and collecting L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof from the medium:
    (A) a protein comprising the amino acid sequence of SEQ ID NO: 2,
    (B) a protein comprising the amino acid sequence of SEQ ID NO: 2 including substitutions, deletions, insertions or additions of one or several amino acid residues, increase of which activity in the bacterium improves L-cysteine-producing ability of the bacterium.

    摘要翻译： L-半胱氨酸，L-胱氨酸，其衍生物或其前体或其混合物通过培养属于具有L-半胱氨酸生产能力并已被修饰的肠杆菌科的细菌产生，使得蛋白质的活性被编码 通过tolC基因，例如在以下（A）或（B）中定义的蛋白质在培养基中增加，并从培养基中收集L-半胱氨酸，L-胱氨酸，其衍生物或其前体或其混合物： （A）包含SEQ ID NO：2的氨基酸序列的蛋白质，（B）包含SEQ ID NO：2的氨基酸序列的蛋白质，包括一个或几个氨基酸残基的取代，缺失，插入或添加，增加 其细菌活性提高细菌的L-半胱氨酸生产能力。