发明公开
EP2258702A3 Purified compositions of 10-Propargyl-10-Deazaaminopterin and method of using same in the treatment of tumors
失效
它们在肿瘤治疗中使用的10-炔丙基-10- deazaaminopterin理解过程方法纯化的组合物
- 专利标题： Purified compositions of 10-Propargyl-10-Deazaaminopterin and method of using same in the treatment of tumors
- 专利标题（中）： 它们在肿瘤治疗中使用的10-炔丙基-10- deazaaminopterin理解过程方法纯化的组合物
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申请号： EP10179892.4申请日： 1997-07-16
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公开(公告)号： EP2258702A3公开(公告)日： 2011-11-30
- 发明人: Colwell, William, T , Degraw, Joseph, I. , Piper, James, R. , Sirotnak, Francis, M.
- 申请人： Sloan-Kettering Institute For Cancer Research , Southern Research Institute , SRI International
- 申请人地址： 1275 York Avenue New York, New York 10021 US
- 专利权人： Sloan-Kettering Institute For Cancer Research,Southern Research Institute,SRI International
- 当前专利权人： Sloan-Kettering Institute For Cancer Research,Southern Research Institute,SRI International
- 当前专利权人地址： 1275 York Avenue New York, New York 10021 US
- 代理机构： Murphy, Colm Damien
- 优先权： US21908P 19960717
- 主分类号： C07D475/08
- IPC分类号： C07D475/08 ; A61K31/505 ; A61K31/519 ; A61K31/555 ; A61K33/24
摘要：
Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacy against human tumors are shown to be far superior to methotexate ("MTX") and are even superior to the newer clinical candidate edatrexate ("EDX"). Moreover, 10-propargyl-10dAM showed a surprising ability to cure tumors such that there was no evidence of tumor growth several weeks after the cessation of therapy. Thus, highly purified compositions containing 10-propargyl-10dAM can be used to treat human tumors, particularly human mammary tumors and human lung cancer.
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