公开(公告)号：EP2258702A3

公开(公告)日：2011-11-30

申请号：EP10179892.4

申请日：1997-07-16

申请人： Sloan-Kettering Institute For Cancer Research ,  Southern Research Institute ,  SRI International

发明人： Colwell, William, T ,  Degraw, Joseph, I. ,  Piper, James, R. ,  Sirotnak, Francis, M.

IPC分类号： C07D475/08 ,  A61K31/505 ,  A61K31/519 ,  A61K31/555 ,  A61K33/24

CPC分类号： C07D475/08 ,  A61K31/505 ,  A61K31/519 ,  A61K31/555 ,  A61K33/24 ,  A61K2300/00 ,  A61K31/475 ,  A61K31/335

摘要： Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacy against human tumors are shown to be far superior to methotexate ("MTX") and are even superior to the newer clinical candidate edatrexate ("EDX"). Moreover, 10-propargyl-10dAM showed a surprising ability to cure tumors such that there was no evidence of tumor growth several weeks after the cessation of therapy. Thus, highly purified compositions containing 10-propargyl-10dAM can be used to treat human tumors, particularly human mammary tumors and human lung cancer.

公开(公告)号：EP2258702A2

公开(公告)日：2010-12-08

申请号：EP10179892.4

申请日：1997-07-16

申请人： Sloan-Kettering Institute For Cancer Research ,  Southern Research Institute ,  SRI International

发明人： Colwell, William, T ,  Degraw, Joseph, I. ,  Piper, James, R. ,  Sirotnak, Francis, M.

IPC分类号： C07D475/08 ,  A61K31/505 ,  A61K31/519 ,  A61K31/555 ,  A61K33/24

CPC分类号： C07D475/08 ,  A61K31/505 ,  A61K31/519 ,  A61K31/555 ,  A61K33/24 ,  A61K2300/00 ,  A61K31/475 ,  A61K31/335

摘要： Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacy against human tumors are shown to be far superior to methotexate ("MTX") and are even superior to the newer clinical candidate edatrexate ("EDX"). Moreover, 10-propargyl-10dAM showed a surprising ability to cure tumors such that there was no evidence of tumor growth several weeks after the cessation of therapy. Thus, highly purified compositions containing 10-propargyl-10dAM can be used to treat human tumors, particularly human mammary tumors and human lung cancer.

摘要翻译： 高度纯化的10-炔丙基-10- deazaaminopterin（10-炔丙基10dAM）的组合物在异种移植模型中测试它们对人类肿瘤的疗效被示为远远优于methotexate（“MTX”）和甚至优于较新的临床候选依达曲沙 （ “EDX”）。 更过，10-炔丙基10dAM表现为治疗肿瘤的令人惊讶的能力，检查thatthere什么样的治疗停止后没有肿瘤生长数周的证据。 因此，含有10-炔丙基10dAM高度纯化的组合物可用于治疗人类肿瘤，特别是人类乳腺肿瘤和人肺癌。