发明公开
- 专利标题： Polymer conjugates of interferon beta-1A and uses thereof
- 专利标题（中）： 干扰素β-1A和它们的用途的聚合物缀合物
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申请号： EP10182477.9申请日： 1999-10-15
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公开(公告)号： EP2260872A3公开(公告)日： 2011-04-27
- 发明人: Pepinsky, Blake , Runkel, Laura , Brickelmaier, Margot , Whitty, Adrian , Hochman, Paula
- 申请人： Biogen Idec MA Inc.
- 申请人地址： 14 Cambridge Center Cambridge, Massachusetts 02142 US
- 专利权人： Biogen Idec MA Inc.
- 当前专利权人： Biogen Idec MA Inc.
- 当前专利权人地址： 14 Cambridge Center Cambridge, Massachusetts 02142 US
- 代理机构： Adams, Harvey Vaughan John
- 优先权： US104572P 19981016; US120161P 19990216
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61P35/00 ; A61P31/12 ; A61K38/21
摘要：
An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
公开/授权文献
- EP2260872B1 Polymer conjugates of interferon beta-1A and uses thereof 公开/授权日：2017-08-30
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