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1.发明公开Polymer conjugates of interferon beta-1A and uses thereof 有权Polymer-Konjugate von Interferon beta-1A und ihre Verwendungen
公开(公告)号：EP1656952A3
公开(公告)日：2006-11-29
申请号：EP06003415.4
申请日：1999-10-15
申请人： Biogen Idec MA Inc.
CPC分类号： A61K47/48215 , A61K38/215 , A61K47/59 , A61K47/60 , A61K47/61 , Y10S930/142
摘要： An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-la. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
摘要翻译： 包含与包含聚亚烷基二醇部分的聚合物偶联的干扰素β1a的干扰素β多肽，其中所述干扰素-β-1a和聚亚烷基二醇部分被排列成使得干扰素-β-1a相对于另一种治疗形式具有增强的活性 干扰素β（干扰素-β-1b），并且与非结合的干扰素-β-1a相比，其活性没有降低。 本发明的缀合物有用地用于治疗以及非治疗性，例如诊断性应用。
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公开(公告)号：EP1739090A2
公开(公告)日：2007-01-03
申请号：EP06010613.5
申请日：1999-10-15
申请人： Biogen Idec MA Inc.
IPC分类号： C07K14/565 , C12N15/62 , C07K19/00
CPC分类号： C07K19/00 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described.
摘要翻译： 描述了融合多肽，其具有包含糖基化干扰素-β（X）的氨基酸序列的氨基酸序列X-Y-Z或其部分。 Y是任选的接头部分; 并且Z是包含除糖基化干扰素-β以外的多肽的至少一部分的多肽。 优选X是人类干扰素-β-1a。 还描述了干扰素-β-1a的突变体。
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3.发明授权
公开(公告)号：EP1656952B1
公开(公告)日：2013-12-18
申请号：EP06003415.4
申请日：1999-10-15
申请人： Biogen Idec MA Inc.
CPC分类号： A61K47/48215 , A61K38/215 , A61K47/59 , A61K47/60 , A61K47/61 , Y10S930/142
摘要： An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
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4.发明公开Polymer conjugates of interferon beta-1A and uses thereof 有权Polymer-Konjugate von Interferon beta-1A und ihre Verwendungen
公开(公告)号：EP2260872A2
公开(公告)日：2010-12-15
申请号：EP10182477.9
申请日：1999-10-15
申请人： Biogen Idec MA Inc.
CPC分类号： A61K47/48215 , A61K38/215 , A61K47/59 , A61K47/60 , A61K47/61 , Y10S930/142
摘要： An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
摘要翻译： 包含与包含聚亚烷基二醇部分的聚合物偶联的干扰素β1a的干扰素β多肽，其中所述干扰素-β-1a和聚亚烷基二醇部分被排列成使得干扰素-β-1a相对于另一种治疗形式具有增强的活性 干扰素β（干扰素-β-1b），并且与非结合的干扰素-β-1a相比，其活性没有降低。 本发明的缀合物有用地用于治疗以及非治疗性，例如诊断性应用。
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公开(公告)号：EP2599503A2
公开(公告)日：2013-06-05
申请号：EP12198907.3
申请日：1999-10-15
申请人： Biogen Idec MA Inc.
CPC分类号： A61K47/48215 , A61K38/215 , A61K47/59 , A61K47/60 , A61K47/61 , Y10S930/142
摘要： An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
摘要翻译： 包含与包含聚亚烷基二醇部分的聚合物偶联的干扰素-β1a的干扰素β多肽，其中干扰素-β-1a和聚亚烷基二醇部分被排列成使得干扰素-β-1a相对于另一种治疗形式的 干扰素β（干扰素-β-1b），并且与未缀合的干扰素-β-1a相比，其活性不降低。 本发明的缀合物有用地用于治疗以及非治疗，例如诊断应用。
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6.发明公开Polymer conjugates of interferon beta-1A and uses thereof 有权聚亚烷基二醇 - Konjugate von Interferon beta-1A和ihre Verwendungen
公开(公告)号：EP1656952A2
公开(公告)日：2006-05-17
申请号：EP06003415.4
申请日：1999-10-15
申请人： Biogen Idec MA, Inc.
CPC分类号： A61K47/48215 , A61K38/215 , A61K47/59 , A61K47/60 , A61K47/61 , Y10S930/142
摘要： An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-la. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
摘要翻译： 包含与包含聚亚烷基二醇部分的聚合物偶联的干扰素β1a的干扰素β多肽，其中所述干扰素-β-1a和聚亚烷基二醇部分被排列成使得干扰素-β-1a相对于另一种治疗形式具有增强的活性 干扰素β（干扰素-β-1b），并且与非结合的干扰素-β-1a相比，其活性没有降低。 本发明的缀合物有用地用于治疗以及非治疗性，例如诊断性应用。
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7.发明公开Polymer conjugates of interferon beta-1A and uses thereof 有权聚合物混合物von Interferon-Beta-1A和Verwendungendafür
公开(公告)号：EP2599503A3
公开(公告)日：2013-07-24
申请号：EP12198907.3
申请日：1999-10-15
申请人： Biogen Idec MA Inc.
CPC分类号： A61K47/48215 , A61K38/215 , A61K47/59 , A61K47/60 , A61K47/61 , Y10S930/142
摘要： An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
摘要翻译： 包含与包含聚亚烷基二醇部分的聚合物偶联的干扰素β1a的干扰素β多肽，其中所述干扰素-β-1a和聚亚烷基二醇部分被排列成使得干扰素-β-1a相对于另一种治疗形式具有增强的活性 干扰素β（干扰素-β-1b），并且与非结合的干扰素-β-1a相比，其活性没有降低。 本发明的缀合物有用地用于治疗以及非治疗性，例如诊断性应用。
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公开(公告)号：EP2260872A3
公开(公告)日：2011-04-27
申请号：EP10182477.9
申请日：1999-10-15
申请人： Biogen Idec MA Inc.
CPC分类号： A61K47/48215 , A61K38/215 , A61K47/59 , A61K47/60 , A61K47/61 , Y10S930/142
摘要： An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
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公开(公告)号：EP1739090A3
公开(公告)日：2009-04-08
申请号：EP06010613.5
申请日：1999-10-15
申请人： Biogen Idec MA Inc.
IPC分类号： C07K14/565 , C12N15/62 , C07K19/00
CPC分类号： C07K19/00 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described.
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