发明公开
EP2264459A2 Method for the early detection of renal disease and injury
审中-公开
Verfahren zumfrühenNachweis einer Nierenkrankheit und -verletzung
- 专利标题： Method for the early detection of renal disease and injury
- 专利标题（中）： Verfahren zumfrühenNachweis einer Nierenkrankheit und -verletzung
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申请号： EP10186256.3申请日： 2005-06-07
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公开(公告)号： EP2264459A2公开(公告)日： 2010-12-22
- 发明人: Devarajan, Prasad , Barasch, Jonathan M
- 申请人： The Children's Hospital Medical Center , The Trustees of Columbia University
- 申请人地址： 3333 Burnet Avenue Cincinnati, Ohio 45229-3039 US
- 专利权人： The Children's Hospital Medical Center,The Trustees of Columbia University
- 当前专利权人： The Children's Hospital Medical Center,The Trustees of Columbia University
- 当前专利权人地址： 3333 Burnet Avenue Cincinnati, Ohio 45229-3039 US
- 代理机构： Finnie, Isobel Lara
- 优先权： US577662P 20040607; US96113 20050331
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; G01N33/536 ; G01N33/537 ; G01N33/543 ; G01N33/551
摘要：
A method and kit for detecting the early onset of renal disease and injury, including renal tubular injury, utilizing NGAL as an early blood serum biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the blood serum following renal tubule cell injury. NGAL protein expression is detected predominantly in proximal tubule cells, in a punctate cytoplasmic distribution reminiscent of a secreted protein. The appearance NGAL in the serum is related to the dose and duration of renal ischemia and nephrotoxemia, and is diagnostic of renal tubule cell injury and renal failure. NGAL detection is also a useful marker for monitoring the nephrotoxic side effects of drugs or other therapeutic agents.
公开/授权文献
- EP2264459B1 Method for the early detection of renal disease and injury 公开/授权日：2019-01-02
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