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    FREEZE-DRIED CONJUGATE AND KIT FOR IMMUNOCHROMATOGRAPHIC POINT-OF-CARE TESTING AND A METHOD USING THE KIT
    1.
    发明授权
    FREEZE-DRIED CONJUGATE AND KIT FOR IMMUNOCHROMATOGRAPHIC POINT-OF-CARE TESTING AND A METHOD USING THE KIT 有权

    公开(公告)号：EP2857837B1

    公开(公告)日：2018-07-25

    申请号：EP13798097.5

    申请日：2013-05-31

    申请人： SD Biosensor Inc.

    发明人： CHOI, Hyoung Gil ,  HONG, Sung Yub ,  HWANG, Hee Young ,  LEE, Hyo Keun

    IPC分类号： G01N33/558 ,  G01N33/532 ,  G01N33/543

    CPC分类号： G01N33/5436 ,  G01N33/49 ,  G01N33/532 ,  G01N33/538 ,  G01N33/558 ,  G01N33/723 ,  G01N33/90

    摘要： The present invention relates to a freeze-dried conjugate structure for immunochromatography, an immunoassay kit comprising the freeze-dried conjugate structure and an immunochromatographic strip, and a method for qualitatively or quantitatively analyzing an analyte in a sample using the immunoassay kit. Because a sample is subjected to immunochromatography after reacting uniformly with a freeze-dried conjugate structure separately prepared according to the present invention externally, quantitative analysis can be performed with high reproducibility and linearity depending on a concentration compared to a conventional assay method which is performed using an immunochromatographic strip comprising a conjugate pad prepared by adsorbing a conjugate. In addition, the freeze-dried conjugate structure of the present invention can be provided in a state in which it is received in a chamber additionally comprising a cap. Thus, it can be stored without contamination and is easy to carry. In addition, the freeze-dried conjugate structure can be rapidly and uniformly dissolved so that it is immediately allowed to react with a mixture of a buffer and a sample and the reaction product can be analyzed by an immunoassay kit. Thus, it is suitable for use in point-of-care testing.

    ESOPHAGEAL MICRORNA EXPRESSION PROFILES IN EOSINOPHILIC ESOPHAGITIS
    3.
    发明授权
    ESOPHAGEAL MICRORNA EXPRESSION PROFILES IN EOSINOPHILIC ESOPHAGITIS 有权
    食管嗜酸性粒细胞表达谱在嗜酸性粒细胞性ESOPHAGITIS中的表达

    公开(公告)号：EP2817417B1

    公开(公告)日：2017-10-25

    申请号：EP13751420.4

    申请日：2013-02-22

    申请人： Children's Hospital Medical Center

    发明人： ROTHENBERG, Marc, E. ,  LU, Thomas, Xuefeng

    IPC分类号： C12Q1/68 ,  C12N15/11

    CPC分类号： C12Q1/6883 ,  C12N15/111 ,  C12N2310/141 ,  C12N2320/10 ,  C12Q2600/158 ,  C12Q2600/178

    摘要： Methods and compositions disclosed herein generally relate to methods of treating eosinophilic esophagitis (EE) and eosinophilic disorders by providing or enhancing a diagnosis of EE and eosinophilic disorders. In particular, the invention relates to obtaining a sample from a patient, then quantifying from the sample an amount of one or more microRNAs (miRNAs) associated with EE, wherein an altered level of the miRNA correlates with a positive diagnosis of EE. An EE diagnosis can then be provided or enhanced, based upon the quantifying step, and an appropriate treatment can be administered to the patient. The invention further relates to diagnostic kits, tests, and/or arrays that can be used to quantify the one or more miRNAs associated with EE, as well as treatments developed to up-regulate or down-regulate one or more miRNAs and/or their downstream pathways relevant to EE or asthma. The invention further relates to the use of IGF1 and IGF1R inhibitors for the treatment of EE and eosinophilic disorders.

    COMPOSITIONS OF ASYMMETRIC INTERFERING RNA AND USES THEREOF
    5.
    发明公开
    COMPOSITIONS OF ASYMMETRIC INTERFERING RNA AND USES THEREOF 审中-公开
    ZUSAMMENSETZUNGEN AUS不对称干扰素RNA在VERWENDUNGEN DAVON

    公开(公告)号：EP3121281A1

    公开(公告)日：2017-01-25

    申请号：EP16187862.4

    申请日：2008-08-27

    申请人： 1Globe Health Institute LLC

    发明人： LI, Chiang, Jia ,  SUN, Xiangao ,  ROGOFF, Harry ,  LI, Youzhi

    IPC分类号： C12N15/113 ,  C12N15/11

    CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2320/53 ,  C12N2330/51

    摘要： The present invention provides double-stranded RNA molecules that are asymmetrical in strand length. The RNA molecule of the invention, the asymmetric RNA duplex, has one or two overhangs at the end. In one aspect, these novel RNA duplex molecules serve as effective mimetics of miRNA. In another aspect, they are designed to function as effective inhibitors of miRNA. Accordingly, the RNA molecules of the present invention can be used to modulate miRNA pathway activities, with tremendous implications for research, drug discovery and development, and treatment of human diseases.

    摘要翻译： 本发明提供在链长度上不对称的双链RNA分子。 本发明的RNA分子，不对称RNA双链体，在末端具有一个或两个突出端。 一方面，这些新型RNA双链体分子用作miRNA的有效模拟物。 另一方面，它们被设计用作miRNA的有效抑制剂。 因此，本发明的RNA分子可用于调节miRNA途径活性，对研究，药物发现和开发以及人类疾病的治疗具有重大意义。

    DEVICE
    7.
    发明公开
    DEVICE 审中-公开
    设备

    公开(公告)号：EP3046521A1

    公开(公告)日：2016-07-27

    申请号：EP14786138.9

    申请日：2014-09-19

    申请人： Crawford Healthcare Ltd.

    发明人： STEPHENSON, Christian

    IPC分类号： A61F13/02 ,  A61F13/00

    CPC分类号： A61F13/00004 ,  A61F13/0206 ,  A61F13/0209 ,  A61F13/0223 ,  A61F13/0226 ,  A61F2013/00089

    摘要： A conformable absorbent device, which comprises a) a wound contact integer, comprising an absorbent component and optionally a cushioning component, b) a liquid-impermeable backing layer, which overlies the distal face of the wound contact integer, and c) a liquid-permeable wound contact layer, which overlies the proximal face of the wound contact integer, characterised in that the proximal face of the wound contact layer comprises a heat-plasticised flexible material; a method for its preparation, and methods of use of the device.

    摘要翻译： 适合的吸收性装置，其包括a）伤口接触整形体，其包括吸收组分和任选的缓冲组分，b）液体不可渗透的背衬层，其覆盖伤口接触整体的远侧面，以及c）液体 - 其覆盖所述伤口接触整体的近侧面，其特征在于，所述伤口接触层的所述近侧面包含热塑性柔性材料; 其制备方法以及该装置的使用方法。