发明公开
- 专利标题： PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS
- 专利标题（中）： 哒嗪因子XIA抑制剂
-
申请号： EP09720875.5申请日： 2009-03-12
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公开(公告)号： EP2265601A1公开(公告)日： 2010-12-29
- 发明人: CORTE, James, R. , HU, Zilun , QUAN, Mimi, L.
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： Route 206 and Province Line Road Princeton NJ 08543-4000 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： Route 206 and Province Line Road Princeton NJ 08543-4000 US
- 代理机构： Beacham, Annabel Rose
- 优先权： US36127 20080313; US145203 20090116
- 国际公布： WO2009114677 20090917
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D413/14 ; C07D417/14 ; C07D498/04 ; A61K31/501 ; A61P7/02
摘要：
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein the variables A, L
1 , L
2 , R
2 , R
11 , and M are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
1 , L
2 , R
2 , R
11 , and M are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
公开/授权文献
- EP2265601B1 PYRIDAZINE DERIVATIVES AS FACTOR XIA INHIBITORS 公开/授权日：2012-02-01
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