- 专利标题: WATER-BASED ADHESIVE SKIN PATCH COMPRISING KETOPROFEN LYSINE SALT
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申请号: EP09724708.4申请日: 2009-03-24
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公开(公告)号: EP2266556B1公开(公告)日: 2018-11-14
- 发明人: INAZUKI, Masahiro
- 申请人: Teikoku Seiyaku Co., Ltd.
- 申请人地址: 567 Sanbonmatsu Higashikagawa-shi, Kagawa 769-2695 JP
- 专利权人: Teikoku Seiyaku Co., Ltd.
- 当前专利权人: Teikoku Seiyaku Co., Ltd.
- 当前专利权人地址: 567 Sanbonmatsu Higashikagawa-shi, Kagawa 769-2695 JP
- 代理机构: Beckmann, Claus
- 优先权: JP2008078486 20080325
- 国际公布: WO2009119601 20091001
- 主分类号: A61K31/192
- IPC分类号: A61K31/192 ; A61K9/70 ; A61K47/02 ; A61K47/10 ; A61K47/30 ; A61P29/00
摘要:
A ketoprofen-containing aqueous patch is provided in which not only operational efficiency in producing is improved, but also the aqueous patch has excellent storage stability and transdermal absorption of ketoprofen. The ketoprofen lysine salt-containing aqueous patch includes a backing layer and an adhesive (paste) layer laminated thereon. The aqueous patch includes as a main active ingredient a ketoprofen lysine salt completely dissolved in a paste including not glycerin but a polyethylene glycol having an average molecular weight of 1000 or less. In the ketoprofen lysine salt-containing aqueous patch, the polyethylene glycol having an average molecular weight of 1000 or less is one or more polyethylene glycols selected from the group consisting of Polyethylene glycol 200, Polyethylene glycol 400, Polyethylene glycol 600, and Polyethylene glycol 1000.
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