公开(公告)号：EP4506020A2

公开(公告)日：2025-02-12

申请号：EP23784017.8

申请日：2023-04-06

Applicant: Tissuelabs Pesquisa E Desenvolvimento Ltda

Inventor： LIGUORI, Gabriel Romero ,  LIGUORI, Tácia Tavares De Aquinas ,  DE SOUZA, Fernanda Carla Bombaldi ,  DE SOUZA, Renata Francielle Bombaldi

IPC: A61L27/14 ,  A61L27/36 ,  A61K35/12 ,  A61K47/06 ,  A61K47/30

Abstract: The present invention is in the field of tissue and organ bioengineering and refers to an enzyme-free process to produce a tissue-specific extracellular matrix solution, based on a decellularized extracellular matrix, comprising: (a) decellularizing a tissue or organ to obtain the isolated extracellular matrix; and (b) hydrolyzing the isolated extracellular matrix in an acidic environment, in the absence of proteolytic enzymes, optionally followed by purification of the solution. Still, the present invention refers to an enzyme-free process to produce a tissue-specific hydrogel. Thus, the present invention also relates to hydrogels produced according to the current processes, and to ancillary inventions, having the tissue-specific extracellular matrix solution, the hydrogel, and/or the products derived from the tissue-specific extracellular matrix solution as the core that connects the inventive aspects disclosed in this document.

公开(公告)号：EP4504801A1

公开(公告)日：2025-02-12

申请号：EP23785265.2

申请日：2023-04-04

Applicant: Ohio State Innovation Foundation

Inventor： GU, Xiangming ,  PALMER, Andre

IPC: C07K17/04 ,  A61K38/42 ,  A61K47/30 ,  B01J13/18 ,  C12N11/04

公开(公告)号：EP2827841B1

公开(公告)日：2024-09-18

申请号：EP13764971.1

申请日：2013-03-15

IPC: A61K9/08 ,  A61K38/00 ,  A61K47/30 ,  A61K38/16 ,  A61P31/00 ,  A61P31/02 ,  A61P31/04 ,  A61P41/00 ,  A01N37/46

CPC classification number: A61K9/06 ,  A61L15/42 ,  A61L15/46 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/0036 ,  A61L2400/0420130101 ,  A01N37/46 ,  A01N37/44 ,  A61K31/715 ,  A61K31/765 ,  A61K38/02 ,  A61K38/16 ,  A61P13/02 ,  A61P17/00 ,  A61P17/02 ,  A61P31/00 ,  A61P31/02 ,  A61P31/04 ,  A61P41/00 ,  A61P5/46 ,  A61P7/02 ,  A61P7/04 ,  A61P3/10 ,  Y02A50/30

公开(公告)号：EP3658625B1

公开(公告)日：2024-06-12

申请号：EP18838499.4

申请日：2018-07-27

IPC: C08L77/00 ,  A61K47/30 ,  A61K47/42 ,  A61K50/00 ,  A61N1/05 ,  A61P9/00 ,  C08L89/06 ,  C08H1/06

CPC classification number: A61K47/42 ,  C08L89/06 ,  A61P9/00 ,  A61K9/0019 ,  A61K9/06 ,  A61K47/34 ,  A61K47/36 ,  C08G69/48 ,  A61N1/056 ,  A61N1/37512 ,  C08H1/06

公开(公告)号：EP4272823A3

公开(公告)日：2024-01-10

申请号：EP23188505.4

申请日：2016-05-27

Applicant: Immunoforge Co., Ltd.

Inventor： JUN, Hee Sook ,  PARK, Eun Young ,  HONG, Yeon Hee

IPC: A61K38/26 ,  A61K38/16 ,  A61K48/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K47/30 ,  A61P21/00

Abstract: Provided are a pharmaceutical composition for preventing or treating muscle atrophy or sarcopenia including glucagon-like peptide-1 (GLP-1), a GLP-1 fragment, a GLP-1 secretion enhancer, a GLP-1 degradation inhibitor, a GLP-1 receptor (GLP-1R) agonist, or exendin-4, and a method of treating muscle atrophy or sarcopenia by using the pharmaceutical composition. When the pharmaceutical composition for preventing or treating muscle atrophy or sarcopenia provided in the present invention is administered to a subject having sarcopenia or muscle atrophy, reduced body weight, skeletal muscle mass, and grip strength, which are caused by sarcopenia or muscle atrophy, and expression levels of genes involved in muscle production may be restored to normal states, and therefore, the composition may be widely applied to the development of effective therapeutic agents for sarcopenia or muscle atrophy.

公开(公告)号：EP4234015A3

公开(公告)日：2023-11-22

申请号：EP23162149.1

申请日：2014-03-17

Applicant: Tolmar, Inc.

Inventor： DUDLEY, Robert E. ,  CONSTANTINIDES, Panayotis P. ,  LONGSTRETH, James A.

IPC: A61K31/568 ,  A61K9/48 ,  A61K47/30 ,  A61P5/26

Abstract: Methods of treating a testosterone deficiency or its symptoms with a pharmaceutical formulation of testosterone esters are provided. The methods are designed toprovide optimum serum testosterone levels over an extended period.

公开(公告)号：EP2704750B1

公开(公告)日：2023-11-01

申请号：EP12777664.9

申请日：2012-04-27

Inventor： FRASER, Christopher ,  KISHIMOTO, Takashi Kei ,  MALDONADO, Roberto, A.

IPC: A61K47/30 ,  A61K9/127 ,  A61K39/38 ,  A61K31/445

公开(公告)号：EP4181962A1

公开(公告)日：2023-05-24

申请号：EP21842780.5

申请日：2021-07-07

Applicant: The Regents of University of California ,  Mayo Foundation for Medical Education and Research ,  Boston Scientific Scimed, Inc.

Inventor： KHADEMHOSSEINI, Alireza ,  KIM, Hanjun ,  CHEN, Yi ,  JABBARZADEH, Ehsan ,  OKLU, Rahmi

IPC: A61K47/30 ,  A61K47/42 ,  C07K14/435 ,  C07K14/78

公开(公告)号：EP4126822A1

公开(公告)日：2023-02-08

申请号：EP21774577.7

申请日：2021-03-24

Applicant: Inversago Pharma Inc.

Inventor： RAVENELLE, Francois ,  VALDES, Norelys ,  BETANCOURT, Aimesther O. ,  GOSSELIN, Patrick

IPC: C07D231/06 ,  A61K31/415 ,  A61K47/30 ,  A61K9/10

公开(公告)号：EP4084830A1

公开(公告)日：2022-11-09

申请号：EP21736205.2

申请日：2021-01-04

Applicant: The Regents of the University of California

Inventor： XU, Ting ,  DEL RE, Christopher ,  KWON, Junpyo

IPC: A61K47/34 ,  A61K47/30