发明公开
EP2266569A3 Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
审中-公开
杂环衍生物及其作为硬脂酰 - 鲨去饱和酶抑制剂的用途
- 专利标题： Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
- 专利标题（中）： 杂环衍生物及其作为硬脂酰 - 鲨去饱和酶抑制剂的用途
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申请号： EP10013035.0申请日： 2005-09-20
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公开(公告)号： EP2266569A3公开(公告)日： 2011-03-09
- 发明人: Kamboj, Rajender , Zhang, Zaihui , Fu, Jian-Min , Kodumuru, Vishnumurthy , Sviridov, Serguei , Sadalapure, Kashinath , Liu, Shifeng , Sun, Shaoyi , Hou, Duanjie , Chakka, Nagasree
- 申请人： Xenon Pharmaceuticals Inc.
- 申请人地址： 3650 Gilmore Way Burnaby, BC V5G 4W8 CA
- 专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人地址： 3650 Gilmore Way Burnaby, BC V5G 4W8 CA
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US611644P 20040920
- 主分类号： A61K31/501
- IPC分类号： A61K31/501 ; A61K31/496 ; A61P3/00 ; A61P3/04 ; A61P3/10 ; A61P3/06 ; A61P1/16 ; C07D403/00
摘要：
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I):
where x, y, G, J, K, L, M, V R 2 , R 3 , R 4 , R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
where x, y, G, J, K, L, M, V R 2 , R 3 , R 4 , R 5 , R 5a , R 6 , R 6a , R 7 , R 7a , R 8 and R 8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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