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公开(公告)号：EP4405347A1
公开(公告)日：2024-07-31
申请号：EP22790413.3
申请日：2022-09-23
发明人： LOFSTRAND, Verner , KIM, Jung Yun , CLEMENT, Helen , CHARIFSON, Paul , JOHNSTONE, Shawn , SABBATANI, Juliette , SCHOLTES, Jan Felix , ZHANG, Wei , SUN, Shaoyi , BURFORD, Kristen
IPC分类号： C07D401/14 , C07D471/04 , C07D491/04 , C07D413/14 , A61K31/4439 , A61P25/08
CPC分类号： C07D401/14 , C07D491/04 , C07D471/04 , C07D413/14
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公开(公告)号：EP3551626A1
公开(公告)日：2019-10-16
申请号：EP17728326.4
申请日：2017-05-19
发明人： ANDREZ, Jean-Christophe , BOGUCKI, David Earl , BURFORD, Kristen, Nicole , CHOWDHURY, Sultan , COHEN, Charles, Jay , DECKER, Shannon, Marie , DEHNHARDT, Christoph, Martin , DEVITA, Robert, Joseph , EMPFIELD, James, Roy , FOCKEN, Thilo , GRIMWOOD, Michael, Edward , HASAN, Syed, Abid , JIA, Qi , JOHNSON, James, Philip, Jr. , WILSON, Michael, Scott , ZENOVA, Alla, Yurevna
IPC分类号： C07D403/12 , C07D213/76 , C07D237/20 , C07D239/69 , C07D413/12 , C07D261/16 , C07D493/10 , C07D277/52 , C07D285/08 , A61K31/426 , A61P25/08
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公开(公告)号：EP3166939A1
公开(公告)日：2017-05-17
申请号：EP15744417.5
申请日：2015-07-07
发明人： ANDREZ, Jean-Christophe , BERGERON, Philippe , BICHLER, Paul Robert , CHOWDHURY, Sultan , DEHNHARDT, Christoph Martin , FOCKEN, Thilo , GONG, Wei , GRIMWOOD, Michael Edward , HASAN, Abid , HEMEON, Ivan William , JIA, Qi , SAFINA, Brian , SUN, Shaoyi , WILSON, Michael Scott , ZENOVA, Alla Yurevna
IPC分类号： C07D403/12 , C07D413/14 , C07D221/22 , C07D401/10 , C07D401/12 , C07D403/10 , C07D413/12 , C07C235/52 , C07D205/04 , C07D207/16 , C07D277/06 , C07D209/02 , C07D305/08 , A61K31/401 , A61P17/04
CPC分类号： C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
摘要： and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
摘要翻译： 本发明提供具有通式（I）的化合物; 及其药学上可接受的盐; 其中变量RA，RAA，下标n，下标q，环A，X2，L，下标m，X1，R1，R2，R3，R4，R5，D和E具有本文所述的含义， 以及使用这些化合物和组合物的方法。
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公开(公告)号：EP2968280A4
公开(公告)日：2016-08-10
申请号：EP14770296
申请日：2014-03-14
发明人： BICHLER PAUL ROBERT , CHOWDHURY SULTAN , DECKER SHANNON MARIE , DEHNHARDT CHRISTOPH MARTIN , FOCKEN THILO , GRIMWOOD MICHAEL EDWARD , HEMEON IVAN WILLIAM , SAFINA BRIAN , SHENG TAO , SUN SHAOYI , WILSON MICHAEL SCOTT , ZENOVA ALLA YUREVNA
IPC分类号： C07D471/04 , A61K31/437 , A61K31/439 , A61P25/00 , A61P29/00 , C07D471/08
CPC分类号： C07D471/04 , C07D471/08 , C07D519/00
摘要： The invention provides compounds having the general formula: [insert formula (I)] (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
摘要翻译： 本发明提供具有以下通式的化合物：[插入式（I）]（I）及其药学上可接受的盐，其中变量RA，下标n，环A，X2，L，下标m，X1，R1，R2，R3 ，R4和RN具有本文所述的含义，含有这些化合物的组合物和使用这些化合物和组合物的方法。
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公开(公告)号：EP2316827B1
公开(公告)日：2016-01-27
申请号：EP10184939.6
申请日：2004-07-29
发明人： Abreo, Melwyn , Chafev, Mikhail , Chakka, Nagasree , Chowdhury, Sultan , Fu, Jian-Min , Gschwend, Heinz, W. , Holladay, Mark, W. , Hou, Duanjie , Kamboj, Rajender , Kodumuru, Vishnumurthy , Li, Wenbao , Liu, Shifeng , Raina, Vandna , Sun, Sengen , Sun, Shaoyi , Sviridov, Serguei , Tu, Chi , Winther, Michael, D. , Zhang, Zaihui
IPC分类号： C07D237/20 , C07D237/24 , A61K31/501 , A61P3/06
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24
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6.发明公开SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开SPIROOXINDOL-VERBINDUNGEN UND DEREN VERWENDUNGEN ALS THERAPEUTIKA
公开(公告)号：EP2942350A1
公开(公告)日：2015-11-11
申请号：EP15001588.1
申请日：2009-10-13
发明人： Chafeev, Mikhail , Fu, Jian-Min , Sun, Shaoyi , Sviridov, Serguei , Jia, Qi , Chowdhury, Sultan , Fraser, Lauren , Langille, Jonathan , Liu, Shifeng , Sun, Jianyu , Wood, Mark , Zenova, Alla , Cadieux, Jean-Jacques , Gauthier, Simon J. , Douglas, Amy Frances , Hsieh, Tom , Chakka, Nagasree , Cikojevic, Zoran
IPC分类号： C07D491/20 , C07D495/20 , C07D498/20 , C07D491/10 , C07D513/20 , A61K31/407 , A61P25/00
CPC分类号： C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及螺 - 羟吲哚化合物，作为立体异构体，对映异构体，其互变异构体或其混合物; 或其药学上可接受的盐，溶剂合物或前药用于治疗和/或预防钠通道介导的疾病或病症，例如疼痛。
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公开(公告)号：EP2350091B1
公开(公告)日：2015-06-03
申请号：EP09741118.5
申请日：2009-10-13
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Lauren , FU, Jianmin , LANGILLE, Jonathan , LIU, Shifeng , SUN, Jianyu , SUN, Shaoyi , SVIRIDOV, Serguei , WOOD, Mark , ZENOVA, Alla
IPC分类号： C07D491/20 , C07D491/107 , A61K31/407 , A61P25/00 , A61P29/00
CPC分类号： C07D491/107 , C07D491/20
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公开(公告)号：EP2245029B1
公开(公告)日：2015-04-15
申请号：EP09711989.5
申请日：2009-02-18
发明人： CHOWDHURY, Sultan , DALES, Natalie , FONAREV, Julia , FU, Jianmin , HOU, Duanjie , JIA, Qi , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D417/04 , C07D417/14 , A61K31/427 , A61P3/00
CPC分类号： C07D417/04 , C07D417/14
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9.发明公开ASYMMETRIC SYNTHESES FOR SPIRO-OXINDOLE COMPOUNDS USEFUL AS THERAPEUTIC AGENTS 审中-公开不对称合成FÜRSPIROOXINDOLVERBINDUNGEN ALS THERAPEUTISCHE WIRKSTOFFE
公开(公告)号：EP2838902A1
公开(公告)日：2015-02-25
申请号：EP13710961.7
申请日：2013-03-11
发明人： SUN, Shaoyi , FU, Jianmin , CHOWDHURY, Sultan , HEMEON, Ivan, William , GRIMWOOD, Michael, Edward , MANSOUR, Tarek, Suhayl
IPC分类号： C07D491/20 , A61K31/407 , A61P25/00
CPC分类号： C07D491/20 , C07D209/34 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D491/107
摘要： This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
摘要翻译： 本发明涉及某些螺 - 羟吲哚衍生物的不对称合成，其可用于治疗和/或预防钠通道介导的疾病或病症如疼痛。
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10.发明公开Method of preparation of Enantiomers of spiro-oxindole compounds 有权Verfahren zur Herstellung von Enantiomere aus Spiro-Oxindol-Verbindungen
公开(公告)号：EP2789617A1
公开(公告)日：2014-10-15
申请号：EP14000690.9
申请日：2010-06-28
IPC分类号： C07D491/22 , A61K31/404 , A61P29/00
CPC分类号： C07D491/20 , A61K31/407 , C07B57/00 , C07B2200/07 , C07D491/22
摘要： This invention is directed to a method of preparation of the (S)-enantiomer of the compound of formula (I):
This (S)-enantiomer is useful for the treatment of diseases or conditions, such as pain, which are ameliorated or alleviated by the modulation of voltage-gated sodium channels.摘要翻译： 本发明涉及式（I）化合物的（S） - 对映异构体的制备方法：该（S） - 对映体可用于治疗疾病或病症如疼痛，其被改善或缓解 通过电压门控钠通道的调制。
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