发明公开
- 专利标题： Binding agents which inhibit myostatin
- 专利标题（中）： 抑制肌肉生长抑制素的结合剂
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申请号： EP10184770.5申请日： 2003-12-19
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公开(公告)号： EP2272864A2公开(公告)日： 2011-01-12
- 发明人: Han, Hq , Min, Hosung , Boone, Thomas Charles
- 申请人： AMGEN INC.
- 申请人地址： Amgen Center, One Amgen Center Drive Thousand Oaks, CA 91320-1789 US
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： Amgen Center, One Amgen Center Drive Thousand Oaks, CA 91320-1789 US
- 代理机构： Care, Alison
- 优先权： US435923P 20021220
- 主分类号： C07K14/475
- IPC分类号： C07K14/475 ; A61K38/17 ; G01N33/68
摘要：
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therepeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and other metabolic disorders including diabetes and obesity.
公开/授权文献
- EP2272864A3 Binding agents which inhibit myostatin 公开/授权日：2011-02-16
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