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24 条记录 (耗时 0.022 秒)

    Binding agents which inhibit myostatin
    1.
    发明公开
    Binding agents which inhibit myostatin 审中-公开
    抑制肌肉生长抑制素的结合剂

    公开(公告)号：EP2272864A2

    公开(公告)日：2011-01-12

    申请号：EP10184770.5

    申请日：2003-12-19

    申请人： AMGEN INC.

    发明人： Han, Hq ,  Min, Hosung ,  Boone, Thomas Charles

    IPC分类号： C07K14/475 ,  A61K38/17 ,  G01N33/68

    CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/00 ,  C07K14/475 ,  C07K2317/21 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/35 ,  C12N2710/14143 ,  G01N33/567 ,  G01N33/74 ,  G01N2333/475

    摘要： The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therepeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and other metabolic disorders including diabetes and obesity.

    摘要翻译： 本发明提供了包含能够结合肌肉生长抑制素并抑制其活性的肽的结合剂。 在一个实施方案中，结合剂包含至少一种直接或间接连接至至少一种载体例如聚合物或Fc结构域的肌肉生长抑制素结合肽。 当施用给动物时本发明的结合剂产生增加的瘦肌肉量并降低脂肪与肌肉的比例。 含有本发明结合剂的治疗组合物可用于治疗肌肉萎缩病症和其他代谢病症，包括糖尿病和肥胖症。

    Peptides and related molecules that bind to tall-1
    9.
    发明公开
    Peptides and related molecules that bind to tall-1 有权
    Peptide und damitzusammenhängendea Tall-1 bindendeMoleküle

    公开(公告)号：EP1921088A3

    公开(公告)日：2009-01-14

    申请号：EP07019762.9

    申请日：2002-05-13

    申请人： Amgen Inc.

    发明人： Min, Hosung ,  Hsu, Hailing ,  Xiong, Fei

    IPC分类号： C07K14/715 ,  C07K7/06 ,  C07K7/08 ,  C12N15/62 ,  C12N15/63 ,  C12N5/10 ,  A61K38/08 ,  A61K38/10

    CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  C07K1/047 ,  C07K14/001 ,  C07K14/4702 ,  C07K14/7151 ,  C07K16/241 ,  C07K2319/30 ,  C07K2319/74 ,  C12N15/1037 ,  C40B40/02

    摘要： The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz 2 Lz 4 wherein the z 2 is an amino acid residue and z 4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae
    a 1 a 2 a 3 CDa 6 La 8 a 9 a 10 Ca 12 a 13 a 14 (SEQ.ID.NO:100),
    b 1 b 2 b 3 Cb 5 b 6 Db 8 Lb 10 b 11 b 12 b 13 b 14 Cb 16 b 17 b 18 (SEQ.ID.N0:104),
    c 1 c 2 c 3 Cc 5 Dc 7 Lc 9 c 10 c 11 c 12 c 13 c 14 Cc 16 c 17 c 18 (SEQ.ID.NO:105),
    d 1 d 2 d 3 Cd 5 d 6 d 7 WDd 10 Ld 13 d 14 d 15 Cd 16 d 17 d 18 (SEQ.ID.N0:106), e 1 e 2 e 3 Ce 5 e 6 e 7 De 9 Le 11 Ke 13 Ce 15 e 16 e 17 e 19 (SEQ.ID.NO:107), f 1 f 2 f 3 Kf 5 Df 5 Lf 9 f 10 f 12 f 13 f 14 (SEQ.ID.NO:109) wherein the substituents are defined in the specification. The invention further comprises compositions of matter of the formula (X 1 ) a -V 1 -(X 2 ) b wherein V 1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.

    摘要翻译： 本发明涉及调节TALL-1活性的治疗剂。 根据本发明，TALL-1的调节剂可以包含氨基酸序列Dz 2 Lz 4，其中z 2是氨基酸残基，z 4是苏氨酰基或异亮氨酰基。 示例性分子包含式a 1 a 2 a 3 CDa 6 La 8 a 9 a 10 Ca 12 a 13 a 14（SEQ ID NO：100），b 1 b 2 b 3 Cb 5 b 6 Db 8的序列 Lb 10 b 11 b 12 b 13 b 14 Cb 16 b 17 b 18（SEQ.ID.N0:104），c 1 c 2 c 3 Cc 5 Dc 7 Lc 9 c 10 c 11 c 12 c 13 c 14 Cc 16 c 17 c 18（SEQ ID NO：105），d 1 d 2 d 3 Cd 5 d 6 d 7 WDd 10 Ld 13 d 14 d 15 Cd 16 d 17 d 18（SEQ.ID.N0：106）， e 1 e 2 e 3 Ce 5 e 6 e 7 De 9 Le 11 Ke 13 Ce 15 e 16 e 17 e 19（SEQ.ID.NO:107），f 1 f 2 f 3 Kf 5 Df 5 Lf 9 f 10 f 12 f 13 f 14（SEQ ID NO：109），其中取代基在说明书中定义。 本发明还包括式（X 1）a -V 1 - （X 2）b的物质组合物，其中V 1是共价连接到一种或多种上述TALL-1调节组合物的载体。 载体和TALL-1调节组合物可以通过TALL-1调节部分的N末端或C末端连接。 优选的载体是Fc结构域，优选的Fc结构域是IgG Fc结构域。

    Peptides and related molecules that bind to tall-1
    10.
    发明公开
    Peptides and related molecules that bind to tall-1 有权
    肽和相关TALL-1结合分子

    公开(公告)号：EP1921088A2

    公开(公告)日：2008-05-14

    申请号：EP07019762.9

    申请日：2002-05-13

    申请人： Amgen Inc.

    发明人： Min, Hosung ,  Hsu, Hailing ,  Xiong, Fei

    IPC分类号： C07K7/06 ,  C07K7/08 ,  C07K14/525 ,  C07K19/00 ,  C12N15/62 ,  C12N15/63 ,  C12N5/10 ,  A61K38/08 ,  A61K38/10

    CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  C07K1/047 ,  C07K14/001 ,  C07K14/4702 ,  C07K14/7151 ,  C07K16/241 ,  C07K2319/30 ,  C07K2319/74 ,  C12N15/1037 ,  C40B40/02

    摘要： The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz 2 Lz 4 wherein the z 2 is an amino acid residue and z 4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae
    a 1 a 2 a 3 CDa 6 La 8 a 9 a 10 Ca 12 a 13 a 14 (SEQ.ID.NO:100),
    b 1 b 2 b 3 Cb 5 b 6 Db 8 Lb 10 b 11 b 12 b 13 b 14 Cb 16 b 17 b 18 (SEQ.ID.N0:104),
    c 1 c 2 c 3 Cc 5 Dc 7 Lc 9 c 10 c 11 c 12 c 13 c 14 Cc 16 c 17 c 18 (SEQ.ID.NO:105),
    d 1 d 2 d 3 Cd 5 d 6 d 7 WDd 10 Ld 13 d 14 d 15 Cd 16 d 17 d 18 (SEQ.ID.N0:106), e 1 e 2 e 3 Ce 5 e 6 e 7 De 9 Le 11 Ke 13 Ce 15 e 16 e 17 e 19 (SEQ.ID.NO:107), f 1 f 2 f 3 Kf 5 Df 5 Lf 9 f 10 f 12 f 13 f 14 (SEQ.ID.NO:109) wherein the substituents are defined in the specification. The invention further comprises compositions of matter of the formula (X 1 ) a -V 1 -(X 2 ) b wherein V 1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.