发明公开
EP2276773A2 COMPOUNDS WITH GLYCIDIC STRUCTURE ACTIVE IN THE THERAPY OF SYSTEMIC AND LOCAL INFLAMMATION
审中-公开
与ACTIVE GLYCIDSTRUKTUR桥在全身和局部炎症的治疗
- 专利标题： COMPOUNDS WITH GLYCIDIC STRUCTURE ACTIVE IN THE THERAPY OF SYSTEMIC AND LOCAL INFLAMMATION
- 专利标题（中）： 与ACTIVE GLYCIDSTRUKTUR桥在全身和局部炎症的治疗
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申请号： EP09741892.5申请日： 2009-05-07
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公开(公告)号： EP2276773A2公开(公告)日： 2011-01-26
- 发明人: LA FERLA, Barbara , NICOTRA, Francesco , BALSARI, Andrea , PALAZZO, Marco , RUMIO, Cristiano
- 申请人： La Ferla, Barbara , Nicotra, Francesco , Balsari, Andrea , Rumio, Cristiano
- 申请人地址： Piazza Guardi 11 20133 Milano IT
- 专利权人： La Ferla, Barbara,Nicotra, Francesco,Balsari, Andrea,Rumio, Cristiano
- 当前专利权人： La Ferla, Barbara,Nicotra, Francesco,Balsari, Andrea,Rumio, Cristiano
- 当前专利权人地址： Piazza Guardi 11 20133 Milano IT
- 代理机构： Minoja, Fabrizio
- 优先权： ITMI20080846 20080509
- 国际公布： WO2009135673 20091112
- 主分类号： C07H7/04
- IPC分类号： C07H7/04 ; C07H15/18 ; A61K31/7034 ; A61P29/00
摘要：
Compounds of the general formula (I) and (II) (including formulae (III) to (V)), wherein X - -CH
2 -, -O-, -S- n = 0-10 Y = -NH-, -NHSO
2 -, -NHSO-, -NHCO-, -S-, -O-, -CH=CH- R
1 -R
7 , equal or different can be hydrogen, alkyl C
1 -C
4 , alkenyl C
2 -C
4 , cycloalkyl C
3 -C
7 , aryl or heteroaryl; may be substituted with one or more alkyl C
1 -C
4 , alkoxyl C
1 -C
4 , alkylthio C
1 -C
4 or halogens; -NR
8 R
9 , where R
8 e R
9 , equal or different, represent hydrogen, alkyl C
1 -C
4 , alkenyl C
2 -C
4 , cycloalkyl C
3 -C
7 , aryl or heteroaryl, may be substituted with one or more C
1 -C
4 , alkoxyl C
1 -C
4 , alkylthio C
1 -C
4 or halogens; -(CH
2 )
n ,-COOR
10 , with n' = 0-4 and R
3 = hydrogen or alkyl C
1 -C
4 , and their addition salts with organic and inorganic acids, or alkaline and alkaline earth metal or ammonium ions, with the exclusion of the compounds having the following formulae ((VI) to (IX)).
2 -, -O-, -S- n = 0-10 Y = -NH-, -NHSO
2 -, -NHSO-, -NHCO-, -S-, -O-, -CH=CH- R
1 -R
7 , equal or different can be hydrogen, alkyl C
1 -C
4 , alkenyl C
2 -C
4 , cycloalkyl C
3 -C
7 , aryl or heteroaryl; may be substituted with one or more alkyl C
1 -C
4 , alkoxyl C
1 -C
4 , alkylthio C
1 -C
4 or halogens; -NR
8 R
9 , where R
8 e R
9 , equal or different, represent hydrogen, alkyl C
1 -C
4 , alkenyl C
2 -C
4 , cycloalkyl C
3 -C
7 , aryl or heteroaryl, may be substituted with one or more C
1 -C
4 , alkoxyl C
1 -C
4 , alkylthio C
1 -C
4 or halogens; -(CH
2 )
n ,-COOR
10 , with n' = 0-4 and R
3 = hydrogen or alkyl C
1 -C
4 , and their addition salts with organic and inorganic acids, or alkaline and alkaline earth metal or ammonium ions, with the exclusion of the compounds having the following formulae ((VI) to (IX)).
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