公开(公告)号：EP2276773A2

公开(公告)日：2011-01-26

申请号：EP09741892.5

申请日：2009-05-07

申请人： La Ferla, Barbara ,  Nicotra, Francesco ,  Balsari, Andrea ,  Rumio, Cristiano

发明人： LA FERLA, Barbara ,  NICOTRA, Francesco ,  BALSARI, Andrea ,  PALAZZO, Marco ,  RUMIO, Cristiano

IPC分类号： C07H7/04 ,  C07H15/18 ,  A61K31/7034 ,  A61P29/00

CPC分类号： C07H7/04 ,  C07H15/18

摘要： Compounds of the general formula (I) and (II) (including formulae (III) to (V)), wherein X - -CH
2 -, -O-, -S- n = 0-10 Y = -NH-, -NHSO
2 -, -NHSO-, -NHCO-, -S-, -O-, -CH=CH- R
1 -R
7 , equal or different can be hydrogen, alkyl C
1 -C
4 , alkenyl C
2 -C
4 , cycloalkyl C
3 -C
7 , aryl or heteroaryl; may be substituted with one or more alkyl C
1 -C
4 , alkoxyl C
1 -C
4 , alkylthio C
1 -C
4 or halogens; -NR
8 R
9 , where R
8 e R
9 , equal or different, represent hydrogen, alkyl C
1 -C
4 , alkenyl C
2 -C
4 , cycloalkyl C
3 -C
7 , aryl or heteroaryl, may be substituted with one or more C
1 -C
4 , alkoxyl C
1 -C
4 , alkylthio C
1 -C
4 or halogens; -(CH
2 )
n ,-COOR
10 , with n' = 0-4 and R
3 = hydrogen or alkyl C
1 -C
4 , and their addition salts with organic and inorganic acids, or alkaline and alkaline earth metal or ammonium ions, with the exclusion of the compounds having the following formulae ((VI) to (IX)).