发明授权
- 专利标题： LYSOSOMAL TARGETING PEPTIDES AND USES THEREOF
- 专利标题（中）： 地看着溶酶体肽及其用途
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申请号： EP09743707.3申请日： 2009-05-07
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公开(公告)号： EP2279210B1公开(公告)日： 2017-04-12
- 发明人: LEBOWITZ, Jonathan, H. , MAGA, John
- 申请人： BioMarin Pharmaceutical Inc.
- 申请人地址： 105 Digital Drive Novato, CA 94949 US
- 专利权人： BioMarin Pharmaceutical Inc.
- 当前专利权人： BioMarin Pharmaceutical Inc.
- 当前专利权人地址： 105 Digital Drive Novato, CA 94949 US
- 代理机构： Venner, Julia Ann
- 优先权： US144106P 20090112; US51336P 20080507
- 国际公布： WO2009137721 20091112
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C07K14/475
摘要：
The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.
公开/授权文献
- EP2279210A2 LYSOSOMAL TARGETING PEPTIDES AND USES THEREOF 公开/授权日：2011-02-02
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