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公开(公告)号：EP2475376A2
公开(公告)日：2012-07-18
申请号：EP10790224.9
申请日：2010-06-17
CPC分类号： A61K38/47 , A61K9/0019 , A61K9/19 , A61K38/30 , A61K47/10 , A61K47/26 , A61K2300/00
摘要： The present invention provides improved formulations for lysosomal enzymes useful for enzyme replacement therapy. Among other things, the present invention provides formulations that preserve or enhance the stability and/or efficacy of a lysosomal enzyme such as acid alpha-glucosidase.
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公开(公告)号：EP2475376B1
公开(公告)日：2016-03-30
申请号：EP10790224.9
申请日：2010-06-17
CPC分类号： A61K38/47 , A61K9/0019 , A61K9/19 , A61K38/30 , A61K47/10 , A61K47/26 , A61K2300/00
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公开(公告)号：EP2279210B1
公开(公告)日：2017-04-12
申请号：EP09743707.3
申请日：2009-05-07
发明人： LEBOWITZ, Jonathan, H. , MAGA, John
IPC分类号： C07K19/00 , C07K14/475
CPC分类号： A61K38/47 , C07K14/65 , C07K2319/06 , C07K2319/33 , C12N9/2408 , C12Y302/0102
摘要： The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.
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