发明公开
EP2287153A1 Synthesis Of Renin Inhibitors Involving A Cycloaddition Reaction
审中-公开
Synthese von Reninhemmern mit einer Cycloadditionsreaktion
- 专利标题： Synthesis Of Renin Inhibitors Involving A Cycloaddition Reaction
- 专利标题（中）： Synthese von Reninhemmern mit einer Cycloadditionsreaktion
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申请号： EP10178025.2申请日： 2006-09-26
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公开(公告)号： EP2287153A1公开(公告)日： 2011-02-23
- 发明人: Mickel, Stuart, John , Marterer, Wolfgang
- 申请人： Novartis AG
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Barbier, Denis Robert
- 优先权： GB0519764 20050928
- 主分类号： C07D207/16
- IPC分类号： C07D207/16 ; C07C251/24 ; C07C237/22
摘要：
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula III,
wherein R, R 1 , and R' are as defined in the specification, or a salt thereof, and a compound of formula IV
wherein R, R 1 , R 2 and R' are as defined in the specification, and processes of manufacturing these.
wherein R, R 1 , and R' are as defined in the specification, or a salt thereof, and a compound of formula IV
wherein R, R 1 , R 2 and R' are as defined in the specification, and processes of manufacturing these.
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