公开(公告)号：EP2287153A1

公开(公告)日：2011-02-23

申请号：EP10178025.2

申请日：2006-09-26

申请人： Novartis AG

发明人： Mickel, Stuart, John ,  Marterer, Wolfgang

IPC分类号： C07D207/16 ,  C07C251/24 ,  C07C237/22

CPC分类号： C07C251/24 ,  C07C231/12 ,  C07D207/08 ,  C07D207/16 ,  C07C237/22

摘要： The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula III,

wherein R, R 1 , and R' are as defined in the specification, or a salt thereof, and a compound of formula IV

wherein R, R 1 , R 2 and R' are as defined in the specification, and processes of manufacturing these.

摘要翻译： 本发明涉及可用于合成药物活性化合物，特别是如阿利吉仑的肾素抑制剂的新方法，新方法步骤和新型中间体。 特别地，本发明涉及制备式III化合物的方法，其中R，R 1和R'如本说明书中所定义，或其盐和式IV化合物，其中R， R 1，R 2和R'如说明书中所定义，及其制造方法。