发明公开
- 专利标题： SELECTIVE CASPASE INHIBITORS AND USES THEREOF
- 专利标题（中）： 选择性CASPASEHEMMER及其用途
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申请号： EP09749369.6申请日： 2009-05-21
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公开(公告)号： EP2288615A1公开(公告)日： 2011-03-02
- 发明人: AHLFORS, Jan-Eric , MEKOUAR, Khalid
- 申请人： New World Laboratories Inc.
- 申请人地址： 500 Cartier Blvd West Laval, Québec H7V 5B7 CA
- 专利权人： New World Laboratories Inc.
- 当前专利权人： New World Laboratories Inc.
- 当前专利权人地址： 500 Cartier Blvd West Laval, Québec H7V 5B7 CA
- 代理机构： HOFFMANN EITLE
- 优先权： US128253P 20080521
- 国际公布： WO2009140765 20091126
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; A61K31/223 ; A61K31/47 ; A61K31/5375 ; A61K31/662 ; A61K38/00 ; C07C237/12 ; C07C237/20 ; C07C317/48 ; C07D215/14 ; C07D295/26 ; C07F9/40 ; C07K5/08 ; C07K5/10 ; C07K14/81 ; C12N9/64
摘要：
The present invention relates to compounds of Formula I, IA, II, HA, III, or IHA and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more caspases. Also described are methods where the compounds of Formula I, IA, II, IIA, III, or IIIA are used in the prevention and/or treatment of various diseases and conditions in subjects, including caspase-mediated diseases such as sepsis, myocardial infarction, ischemic stroke, spinal cord injury (SCI), traumatic brain injury (TBI) and neurodegenerative disease (e.g. multiple sclerosis (MS) and Alzheimer's, Parkinson's, and Huntington's diseases).
公开/授权文献
- EP2288615B1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF 公开/授权日：2017-06-21
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