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公开(公告)号：EP4446307A1
公开(公告)日：2024-10-16
申请号：EP22892084.9
申请日：2022-11-11
发明人： GAO, Jie , CHENG, Huimin , CHENG, Jun , ZHANG, Peiyu
IPC分类号： C07C219/08 , C07K5/062 , A61K31/223 , A61P1/06
摘要： The present invention relates to compounds of Formula I and Formula II and the use thereof in the treatment of metabolic diseases such as liver fibrosis and non-alcoholic hepatitis. Specifically, provided are the compounds as shown, and pharmaceutically acceptable salts or esters, prodrug, stereoisomers, hydrates, solvates, crystalline forms and metabolite forms thereof, or any combination or mixture thereof in the preparation of a drug or reagent, the drug being used for at least one of the following: A-(L 1 ) x -A' (Formula I); A 1 -(L 1 ) x -A 1 ' (Formula II).
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2.发明公开
公开(公告)号：EP4342533A3
公开(公告)日：2024-05-29
申请号：EP23214305.7
申请日：2020-06-10
申请人： Axalbion SA
发明人： POIROT, Olivier , WOODCOCK, Ashley
IPC分类号： A61K31/223 , A61P11/14
CPC分类号： A61K31/223 , A61P11/14
摘要： The present invention pertains generally to the field of therapy. More specifically the present invention pertains to a certain compound, [((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester (also referred to herein as "AX-8" or "Gly-O-iPr"), as described herein, for use in a method of treatment of the human or animal body by therapy, more specifically, for use in a method of treatment of chronic cough (CC), including, for example, refractory chronic cough (RCC) and idiopathic chronic cough (ICC), as described herein.
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公开(公告)号：EP4296670A3
公开(公告)日：2024-03-13
申请号：EP23188362.0
申请日：2019-07-30
申请人： Alzheon, Inc.
发明人： Hey, John , Kocis, Petr , Tolar, Martin
IPC分类号： A61K31/221 , A61K31/222 , A61K31/223 , A61K31/225 , A61K31/255 , A61P25/28 , G01N33/50 , G01N33/52
摘要： Provided herein is the use of a compound of Formula I:
or a pharmaceutically acceptable salt thereof, for treating a disease characterized by amyloid and amyloid-like aggregates, e.g., Alzheimer's disease.-
公开(公告)号：EP3980003B1
公开(公告)日：2023-12-13
申请号：EP20732556.4
申请日：2020-06-10
发明人： POIROT, Olivier , WOODCOCK, Ashley
IPC分类号： A61K31/223 , A61P11/14
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公开(公告)号：EP3226883B1
公开(公告)日：2023-11-22
申请号：EP15865547.2
申请日：2015-12-03
发明人： DVASHI, Zeev , POLLACK, Ayala
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公开(公告)号：EP3611159B1
公开(公告)日：2023-01-25
申请号：EP19188210.9
申请日：2014-07-08
发明人： GOLDSTEIN, David, S. , HOLMES, Courtney , ALKEN, Rudolf-Giesbert , SCHNEIDER, Frank , ZHANG, Chengzhi
IPC分类号： C07C229/08 , C07C229/22 , A61K31/223 , A61P25/00
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公开(公告)号：EP3364958B1
公开(公告)日：2023-01-04
申请号：EP16858326.8
申请日：2016-10-21
发明人： FETALVERO, Kristina Michelle , NARAYAN, Sridhar , O'NEILL, David John , SAIAH, Eddine , SENGUPTA, Shomit
IPC分类号： C07D307/33 , C07F7/08 , C07C237/30 , C07C237/06 , C07C233/49 , C07D257/04 , C07C229/28 , A61K38/00 , C07C311/06 , A61K45/06 , C07C311/13 , A61K31/198 , A61K31/223 , A61K31/275 , A61K31/41 , A61K31/695 , C07C261/04 , C07C311/51 , A61K31/135 , A61K31/137
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公开(公告)号：EP3113843B1
公开(公告)日：2022-12-14
申请号：EP14884697.5
申请日：2014-07-01
发明人： Tuffley, Mark
IPC分类号： A61K31/155 , A61K31/055 , A61K31/355 , A61K31/375 , A61K31/51 , A61K31/525 , A61K31/223 , A61K33/18 , A61K33/24 , A61K8/67 , A61P3/02 , A61P17/02
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公开(公告)号：EP4065549A1
公开(公告)日：2022-10-05
申请号：EP20891432.5
申请日：2020-11-25
发明人： AHMAR, Siawash , KIM, Jung Yun , LAI, Ping Shan , OMEARA, Jeffrey Alan , PIRI SEDIGH, Azadeh , TO, Quang Huy
IPC分类号： C07C235/46 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/223 , A61K31/27 , A61K31/277 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/4015 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/4406 , A61K31/495 , A61K31/4985
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公开(公告)号：EP3989999A1
公开(公告)日：2022-05-04
申请号：EP20737378.8
申请日：2020-06-29
IPC分类号： A61K38/05 , A61K31/223 , A61P21/00
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