发明公开
EP2297075A1 DIHYDRO ISO CA-4 ET ANALOGUES : PUISSANTS CYTOTOXIQUES, INHIBITEURS DE LA POLYMERISATION DE LA TUBULINE
审中-公开
DIHYDROISO-CA-4 UND ANALOGA：WIRKSAME CYTOTOXISCHE VERBINDUNGEN，INHIBITOREN DER TUBULINPOLYMERISATION
- 专利标题： DIHYDRO ISO CA-4 ET ANALOGUES : PUISSANTS CYTOTOXIQUES, INHIBITEURS DE LA POLYMERISATION DE LA TUBULINE
- 专利标题（英）： Dihydro-iso-ca-4 and analogues: potent cytotoxics, inhibitors of tubulin polymerization
- 专利标题（中）： DIHYDROISO-CA-4 UND ANALOGA：WIRKSAME CYTOTOXISCHE VERBINDUNGEN，INHIBITOREN DER TUBULINPOLYMERISATION
-
申请号： EP09757598.9申请日： 2009-06-04
-
公开(公告)号： EP2297075A1公开(公告)日： 2011-03-23
- 发明人: ALAMI, Mouâd , MESSAOUDI, Samir , HAMZE, Abdallah , PROVOT, Olivier , BRION, Jean-Daniel , LIU, Jian-Miao , BIGNON, Jérôme , BAKALA, Joanna
- 申请人： Centre National de la Recherche Scientifique (C.N.R.S)
- 申请人地址： 3, rue Michel Ange 75016 Paris FR
- 专利权人： Centre National de la Recherche Scientifique (C.N.R.S)
- 当前专利权人： Centre National de la Recherche Scientifique (C.N.R.S)
- 当前专利权人地址： 3, rue Michel Ange 75016 Paris FR
- 代理机构： Warcoin, Jacques
- 优先权： FR0853694 20080604
- 国际公布： WO2009147217 20091210
- 主分类号： C07C43/20
- IPC分类号： C07C43/20 ; C07C69/013 ; C07C217/00 ; C07C229/12 ; C07C255/37 ; C07C271/44 ; C07D209/12 ; C07D317/54 ; C07F9/12 ; A61K31/09 ; A61K31/136 ; A61K31/222 ; A61K31/277 ; A61K31/295 ; A61P35/00
摘要：
The present invention relates to compounds of formula (I) below in which: - R
1 and R
3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, - R
2 and R
4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, - A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, - X represents a nitrogen atom or a CH group, and - Z
1 represents a hydrogen atom or a halogen atom, preferably fluorine, and - Z
2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C
1 to C
4 alkyl group, an aryl group or a -CN, -SO
2 NR
12 R
13 , ‑SO
2 R
9 , -COOR
15 or ‑COR
15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.
1 and R
3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, - R
2 and R
4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, - A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, - X represents a nitrogen atom or a CH group, and - Z
1 represents a hydrogen atom or a halogen atom, preferably fluorine, and - Z
2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C
1 to C
4 alkyl group, an aryl group or a -CN, -SO
2 NR
12 R
13 , ‑SO
2 R
9 , -COOR
15 or ‑COR
15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.
信息查询
