发明公开
- 专利标题： A PROCESS OF PURIFYING COAGULATION FACTOR VIII
- 专利标题（中）： 清理方法凝血因子VIII
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申请号： EP09769279.2申请日： 2009-06-24
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公开(公告)号： EP2300497A1公开(公告)日： 2011-03-30
- 发明人: BORGVALL, Carin , ERICSSON, Ulrika , GILLJAM, Gustav , JERNBERG, Mats , WINGE, Stefan
- 申请人： Octapharma AG
- 申请人地址： Seidenstrasse 2 8853 Lachen CH
- 专利权人： Octapharma AG
- 当前专利权人： Octapharma AG
- 当前专利权人地址： Seidenstrasse 2 8853 Lachen CH
- 代理机构： von Kreisler, Alek
- 优先权： EP08158893 20080624; US129402P 20080624
- 国际公布： WO2009156430 20091230
- 主分类号： C07K14/755
- IPC分类号： C07K14/755
摘要：
A process of purifying or enriching coagulation FVIII employing chromatography comprising the steps of providing a fraction containing FVIII in an aqueous solution having a high ionic strength; contacting the fraction containing FVIII with a multimodal resin; optionally washing the multimodal resin having FVIII adsorbed with an aqueous washing buffer; eluting FVIII containing fractions by an aqueous elution buffer comprising at least one amino acid which is positively charged at pH 6 to 8; and optionally collecting FVIII containing fractions in purified or enriched form.
公开/授权文献
- EP2300497B1 A PROCESS OF PURIFYING COAGULATION FACTOR VIII 公开/授权日：2012-08-08
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