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156 条记录 (耗时 0.027 秒)

    METHOD FOR ISOLATION OF RECOMBINANTLY PRODUCED PROTEINS
    6.
    发明公开
    METHOD FOR ISOLATION OF RECOMBINANTLY PRODUCED PROTEINS 审中-公开

    公开(公告)号：EP3467116A1

    公开(公告)日：2019-04-10

    申请号：EP18185708.7

    申请日：2006-03-29

    申请人： Octapharma AG

    发明人： Winge, Stefan

    IPC分类号： C12P21/02 ,  C07K14/755

    摘要： The present invention provides a method for increasing the yield of a protein produced by cultivating eukaryotic cells and adding an ionic substance to the culture medium prior to harvest of the protein. Suitable ionic substances are the salts of the Hofmeister series, amino acids and peptone.

    A PROCESS FOR MANUFACTURING FACTOR VIII HAVING AN IMPROVED RATIO OF FVIII:C/FVIII:AG
    8.
    发明公开
    A PROCESS FOR MANUFACTURING FACTOR VIII HAVING AN IMPROVED RATIO OF FVIII:C/FVIII:AG 有权
    用于生产第八因子与FVIII改善比率：C / FVIII：AG

    公开(公告)号：EP3097118A1

    公开(公告)日：2016-11-30

    申请号：EP15700725.3

    申请日：2015-01-20

    申请人： Octapharma AG

    发明人： WINGE, Stefan ,  DADAIAN, Marina ,  JOHANSSON, Erica ,  FUCHS, Birte

    IPC分类号： C07K14/755 ,  A61K38/37

    CPC分类号： C07K14/755 ,  A61K38/00 ,  C07K1/22

    摘要： A process for manufacturing of a Factor VIII product having a ratio of FVIII:C/FVIII:Ag of at least 0.7 in the Factor VIII product by using chromatography wherein at least one chromatographic step is performed by means of employing; An affinity chromatography resin having an affinity for specifically binding of Factor VIII which is effected by an affinity ligand which is immobilised on the affinity chromatography resin, said affinity ligand is a 13 kD yeast derived Fab antibody fragment directed to the Factor VIII molecule. An anionic chromatography resin. A size exclusion resin. A Factor VIII product obtainable according to the process with a monomer content of >98% for treatment of haemophilia and avoiding formation of inhibitors.

    ASSAY AND METHOD FOR THE IDENTIFICATION OF INDIVIDUAL RESPONSIVENESS TO IMMUNOGLOBULIN THERAPY
    10.
    发明公开
    ASSAY AND METHOD FOR THE IDENTIFICATION OF INDIVIDUAL RESPONSIVENESS TO IMMUNOGLOBULIN THERAPY 审中-公开
    含量测定和方法识别个体反应的免疫球蛋白疗法

    公开(公告)号：EP2718461A1

    公开(公告)日：2014-04-16

    申请号：EP12726113.9

    申请日：2012-06-06

    申请人： Octapharma AG

    发明人： MEUER, Stefan ,  GIESE, Thomas ,  JACOBI, Christian ,  HAAG, Stefan ,  RÖMISCH, Jürgen

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156

    摘要： A method for determining the likelihood of response of an individual,suffering from a disease,towards immunoglobulin therapy comprising the steps of ⋅ providing a sample containing B-and T-lymphocytes, natural killer cells, invariant T-cells and monocytes of the individual; ⋅ genotyping of at least one of the polynucleotides of an ADAMTS9-Intron;a KLHDC8A-Intron or of a flanking region of the CD14 gene, and ⋅ awarding the value of 1 for the homozygous Single Nucleotide Polymorphism combinations, which suggests that the blood sample stems from a person which will not respond to immunoglobulin treatment, ⋅ while awarding the value of 0 for SNP not meeting that criteria, which suggests that the blood sample stems from a person which will respond to immunoglobulin treatment.