发明公开
- 专利标题： PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS
- 专利标题（中）： 抑制剂磷脂酰肌醇3激酶
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申请号： EP09767836.1申请日： 2009-06-19
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公开(公告)号： EP2303890A2公开(公告)日： 2011-04-06
- 发明人: QIAN, Dapeng , HAN, Amy, Qi , HAMILTON, Mark , WANG, Eric
- 申请人： Progenics Pharmaceuticals, Inc.
- 申请人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591 US
- 专利权人： Progenics Pharmaceuticals, Inc.
- 当前专利权人： Progenics Pharmaceuticals, Inc.
- 当前专利权人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591 US
- 代理机构： Lucas, Brian Ronald
- 优先权： US73915P 20080619
- 国际公布： WO2009155527 20091223
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D487/02 ; C07D403/02 ; A61K31/437 ; A61P35/00
摘要：
Provided are compounds according to Formula (I), or stereoisomer, prodrug, polymorph, or pharmaceutically acceptable salt forms thereof, wherein X, Y, R
1 , R
6 , R
7 , and R
8 are as defined, which compounds are effective inhibitors of PI3-kinase and/or other medically and clinically relevant kinases. Also provided are pharmaceutical compositions and methods of using the compounds and compositions as PB -kinase and kinase inhibitors. More particularly, the compounds of the invention provide treatments and therapeutics for human diseases regulated by, or associated with, the activity of, PI3-kinases and/or protein kinases, or mutant or variant forms thereof.
1 , R
6 , R
7 , and R
8 are as defined, which compounds are effective inhibitors of PI3-kinase and/or other medically and clinically relevant kinases. Also provided are pharmaceutical compositions and methods of using the compounds and compositions as PB -kinase and kinase inhibitors. More particularly, the compounds of the invention provide treatments and therapeutics for human diseases regulated by, or associated with, the activity of, PI3-kinases and/or protein kinases, or mutant or variant forms thereof.
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