公开(公告)号：EP2303890A2

公开(公告)日：2011-04-06

申请号：EP09767836.1

申请日：2009-06-19

申请人： Progenics Pharmaceuticals, Inc.

发明人： QIAN, Dapeng ,  HAN, Amy, Qi ,  HAMILTON, Mark ,  WANG, Eric

IPC分类号： C07D487/04 ,  C07D487/02 ,  C07D403/02 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  C07D498/04 ,  C07D513/04

摘要： Provided are compounds according to Formula (I), or stereoisomer, prodrug, polymorph, or pharmaceutically acceptable salt forms thereof, wherein X, Y, R
1 , R
6 , R
7 , and R
8 are as defined, which compounds are effective inhibitors of PI3-kinase and/or other medically and clinically relevant kinases. Also provided are pharmaceutical compositions and methods of using the compounds and compositions as PB -kinase and kinase inhibitors. More particularly, the compounds of the invention provide treatments and therapeutics for human diseases regulated by, or associated with, the activity of, PI3-kinases and/or protein kinases, or mutant or variant forms thereof.