发明公开
EP2318382A1 NOUVEAUX DERIVES IMIDAZO[1,2-a]PYRIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET
审中-公开
NEW咪唑并[1,2-A]吡啶衍生物，METHOD FOR THEIR，它们作为药物，药物组合物的新用途特别是作为MET抑制剂
- 专利标题： NOUVEAUX DERIVES IMIDAZO[1,2-a]PYRIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET
- 专利标题（英）： Novel imidazo[1,2-a]pyridine derivatives, method for the preparation thereof, use thereof as medicaments, pharmaceutical compositions and novel use in particular as met inhibitors
- 专利标题（中）： NEW咪唑并[1,2-A]吡啶衍生物，METHOD FOR THEIR，它们作为药物，药物组合物的新用途特别是作为MET抑制剂
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申请号： EP09737061.3申请日： 2009-07-16
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公开(公告)号： EP2318382A1公开(公告)日： 2011-05-11
- 发明人: DAMOUR, Dominique , NEMECEK, Conception , NEMECEK, Patrick , WENTZLER, Sylvie
- 申请人： Sanofi-Aventis
- 申请人地址： 174 Avenue de France 75013 Paris FR
- 专利权人： Sanofi-Aventis
- 当前专利权人： Sanofi-Aventis
- 当前专利权人地址： 174 Avenue de France 75013 Paris FR
- 代理机构： Le Coupanec, Pascale A.M.P.
- 优先权： FR0804085 20080718; FR0902409 20090519
- 国际公布： WO2010007317 20100121
- 主分类号： C07D277/82
- IPC分类号： C07D277/82 ; C07D471/04 ; A61K31/437 ; A61P35/00
摘要：
The invention relates to the novel products of formula (I): in which: Ra is H, Hal, aryl or heteroaryl, which are optionally substituted; Rb is H, Rc, -COORc-CO-Rc or -CO-NRcRd; where Rc is alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd is H, alk or cycloalkyl; these products being in all the isomer forms and the salts, as medicaments, in particular as MET inhibitors.
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