-
1.发明公开DERIVES IMIDAZO [1,2-A] PYRIMIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET UTILISATION COMME INHIBITEURS DE MET 审中-公开咪唑并[1,2-A]嘧啶衍生物，METHOD FOR THEIR，用作药物，药物组合物以及它们作为MET抑制剂
公开(公告)号：EP2318414A2
公开(公告)日：2011-05-11
申请号：EP09737062.1
申请日：2009-07-16
申请人： Sanofi-Aventis
发明人： BACQUE, Eric , DAMOUR, Dominique , NEMECEK, Conception , NEMECEK, Patrick , SCHIO, Laurent , WENTZLER, Sylvie
IPC分类号： C07D487/04 , A61K31/5377 , A61K31/519 , A61P35/00 , C07D277/82
CPC分类号： C07D277/82 , C07D487/04
摘要： The invention relates to the novel products of formula (I): in which: n = 0,1 or 2; X is H, Hal or alk; R is H, NH
2 , NHalk or N(alk)
2 ; Ra is H, Hal, -O-cycloalkyl, -O-alkyl, -O-aryl, -O-heteroaryl, ‑NRd(cycloalkyl), ‑NRd(alkyl), -NRd(aryl), -NRd(heteroaryl), alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, all optionally substituted; Rb is H, Rc, -COORc-CO-Rc or -CO-NRcRd; where Rc is alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd is H, alk or cycloalkyl; these products being in all the isomer forms and the salts, as medicaments, in particular as MET inhibitors.-
2.发明公开NOUVEAUX DERIVES DE 6-TRIAZOLOPYRIDAZINE-SULFANYL BENZOTHIAZOLE ET BENZIMIDAZOLE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET 有权新的6 TRIAZOLOPYRIDAZINSULFANYL苯并噻唑和苯并咪唑衍生物，用于他们对使用药品和药物组合物及其新用途AS MET抑制剂
公开(公告)号：EP2178881A2
公开(公告)日：2010-04-28
申请号：EP08845285.9
申请日：2008-08-06
申请人： Sanofi-Aventis
IPC分类号： C07D487/04 , A61K31/5025 , A61P7/00 , A61P25/00 , A61P35/00 , A61P9/00 , A61P11/00 , C07D249/12 , C07D237/20 , A61P19/02 , A61P11/06 , A61P9/10 , A61P7/02 , A61P3/10 , A61P3/00 , C07D487/02 , C07D237/06 , C07D249/10 , C07D235/04 , C07D277/82
CPC分类号： C07D487/04 , A61K31/5025 , C07D277/82 , C07D417/12
摘要： The invention relates to novel products of formula (I): where ---- is a single or double bond, Ra = H, HaI, alkoxy, O-cycloalkyl, heteroaryl,.phenyl, NHCOaIk, NHCOcycloalk or NR1 R2; X = S, SO or SO2; A = NH or S; W = H, alkyl or COR with R = cycloalkyl; alkyl, optionally substituted with NR3R4, alkoxy, hydroxy, phenyl, heteroaryl, or heterocycloalkyl; alkoxy optionally substituted by NR3R4, in other words a O-(CH2)n-NR3R4 group, a O-phenyl or O-(CH2)n-phenyl group, with the phenyl optionally substituted and n= 1 to 4; where in the NR1 R2 group; R1 = H or alk and R2 = H, cycloalkyl or alkyl; R3 and R4 = H, alk, cycloalkyl, heteroaryl or phenyl, R1, R2 and/or R3.R4 form a ring with N optionally including O, S, N and/or NH; all heterocycloalkyl, heteroaryl and phenyl and cyclic groups being optionally substituted, said products being in al the isomeric forms and all salts as medicaments in particular as MET inhibitors.
-
3.发明公开DERIVES DE 6-ARYL/HETER0ALKYL0XY BENZOTHIAZOLE ET BENZIMIDAZOLE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE CMET 审中-公开6 - 芳基/ HETEROALKYLOXYBENZOTHIAZOL- AND苯并咪唑衍生物，METHOD FOR PRODUCING药物，药物组合物和新的应用中的使用，特别是作为C-MET抑制剂
公开(公告)号：EP2205568A1
公开(公告)日：2010-07-14
申请号：EP08869645.5
申请日：2008-10-16
申请人： Sanofi-Aventis
IPC分类号： C07D235/30 , C07D277/82 , C07D417/12 , A61K31/4184 , A61K31/428 , A61P35/00 , A61P25/00
CPC分类号： C07D235/30 , C07D235/32 , C07D277/82 , C07D417/12
摘要： The invention relates to novel products of the formula (I) in which : R is H, HaI or AIk; A is NH or S; R5 is H or Alk optionally substituted by one or more HaI; R6 is an optionally substituted aryl or heteroaryl; W is H or COR7 in which R7 is a cycloalkyl, an optionally substituted alkyl, an optionally substituted alkoxy or NR1 R2 with one of R1 and R2 being H or alk while the other of R1 and R2 is a cycloakyl or an optionally substituted alkyl; or R1 and R2 form together with N to which they are bonded; a cyclic radical optionally including one or more optionally substituted O, S, N and NH; the invention also relates to said products in any of their isomer forms or as salts, and they can be used as drugs, in particular as c-Met inhibitors.
-
4.发明公开NOUVEAUX DERIVES IMIDAZO[1,2-a]PYRIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET 审中-公开NEW咪唑并[1,2-A]吡啶衍生物，METHOD FOR THEIR，它们作为药物，药物组合物的新用途特别是作为MET抑制剂
公开(公告)号：EP2318382A1
公开(公告)日：2011-05-11
申请号：EP09737061.3
申请日：2009-07-16
申请人： Sanofi-Aventis
IPC分类号： C07D277/82 , C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D277/82 , C07D471/04
摘要： The invention relates to the novel products of formula (I): in which: Ra is H, Hal, aryl or heteroaryl, which are optionally substituted; Rb is H, Rc, -COORc-CO-Rc or -CO-NRcRd; where Rc is alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd is H, alk or cycloalkyl; these products being in all the isomer forms and the salts, as medicaments, in particular as MET inhibitors.
-
5.发明公开NOUVEAUX DERIVES TRIAZOLO(4,3-a)PYRIDINE,LEUR PROCEDE DE PREPARATION,LEUR APPLICATION A TITRE DE MEDICAMENTS,COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET 审中-公开NEW三唑并（4,3-A）吡啶衍生物，METHOD FOR THE PRODUCTION，它们作为药物，药物组合物和新的应用，尤其是作为MET抑制剂
公开(公告)号：EP2310366A2
公开(公告)日：2011-04-20
申请号：EP09736253.7
申请日：2009-07-16
申请人： Sanofi-Aventis
IPC分类号： C07D213/02 , C07D249/12 , C07D471/04 , A61K31/437 , A61P37/08 , A61P35/00 , A61P25/00 , A61P21/00 , A61P27/00 , A61P19/02 , A61P11/06 , A61P7/02 , A61P3/00 , A61K31/5377 , C07D277/82 , C07D213/61 , C07D213/26 , A61K31/496 , A61K31/428 , A61P17/06
CPC分类号： A61K31/428 , A61K31/437 , A61K31/496 , A61K31/5377 , C07D471/04
摘要： The invention relates to the novel products of formula (I): in which: Ra represents H, Hal, aryl or heteroaryl, which is optionally substituted; Rb represents H, Rc, -COORc-CO-Rc or -CO-NRcRd; where Rc represents alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd represents H, alk or cycloalkyl; these products being in all the isomer forms and the salts, as medicaments, in particular as MET inhibitors.
-
-
-
-
搜索结果
5 条记录 (耗时 0.016 秒)
