发明授权
EP2321283B1 2,6-DIAMINO-PYRIMIDIN-5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS
有权
2,6-二氨基 - 嘧啶-5-基甲酰胺于或SYK激酶JAK抑制剂
- 专利标题： 2,6-DIAMINO-PYRIMIDIN-5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS
- 专利标题（中）： 2,6-二氨基 - 嘧啶-5-基甲酰胺于或SYK激酶JAK抑制剂
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申请号： EP09755219.4申请日： 2009-04-16
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公开(公告)号： EP2321283B1公开(公告)日： 2016-07-13
- 发明人: BAUER, Shawn, M. , JIA, Zhaozhong, J. , SONG, Yonghong , XU, Qing , MEHROTRA, Mukund , ROSE, Jack, W. , HUANG, Wolin , VENKATARAMANI, Chandrasekar , PANDEY, Anjali
- 申请人： Portola Pharmaceuticals, Inc.
- 申请人地址： 270 East Grand Avenue Suite 22 South San Francisco California 94080 US
- 专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人： Portola Pharmaceuticals, Inc.
- 当前专利权人地址： 270 East Grand Avenue Suite 22 South San Francisco California 94080 US
- 代理机构： Campbell, Patrick John Henry
- 优先权： US120348P 20081205; US120344P 20081205; US45417P 20080416; US45406P 20080416; US120341P 20081205; US45399P 20080416
- 国际公布： WO2009145856 20091203
- 主分类号： C07D239/48
- IPC分类号： C07D239/48 ; C07D401/12 ; C07D403/12 ; C07D413/12 ; C07D417/12 ; A61P35/00 ; A61P9/00 ; A61K31/506
摘要：
The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.
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