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1.发明公开2, 6-DIAMINO-PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS 有权2,6-二氨基 - 嘧啶-5-基甲酰胺于或SYK激酶JAK抑制剂
公开(公告)号：EP2321283A1
公开(公告)日：2011-05-18
申请号：EP09755219.4
申请日：2009-04-16
发明人： BAUER, Shawn, M. , JIA, Zhaozhong, J. , SONG, Yonghong , XU, Qing , MEHROTRA, Mukund , ROSE, Jack, W. , HUANG, Wolin , VENKATARAMANI, Chandrasekar , PANDEY, Anjali
IPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61P35/00 , A61P9/00 , A61K31/506
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.
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2.发明授权2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS 有权2,6-二氨基 - 吡啶基-5-Y-羧酰胺ALS SYK-ODER JAK-KINASEHEMMER
公开(公告)号：EP2323993B1
公开(公告)日：2015-06-03
申请号：EP09742982.3
申请日：2009-04-16
发明人： JIA, Zhaozhong, J. , VENKATARAMANI, Chandrasekar , HUANG, Wolin , MEHROTRA, Mukund , SONG, Yonghong , XU, Qing , BAUER, Shawn, M. , PANDEY, Anjali , KANE, Brian , ROSE, Jack, W.
IPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61P35/00 , A61P9/00 , A61K31/506 , C07D407/12 , C07D409/12
CPC分类号： A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of formula I-V and tattooers thereof or pharmaceutically acceptable salts, esters, and pro drugs thereof which are inhibitors of sky kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
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公开(公告)号：EP2938596B1
公开(公告)日：2017-11-01
申请号：EP13822069.4
申请日：2013-12-27
发明人： PANDEY, Anjali , ROSE, Jack, W.
IPC分类号： C07D213/75
CPC分类号： C12N9/6432 , B01D15/38 , B01D15/3804 , C07D213/75 , C07D221/06
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4.发明公开COMPOUNDS AND METHODS FOR PURIFICATION OF SERINE PROTEASES 有权VERFAHREN ZUR REINIGUNG VON SERINPROTEASEN
公开(公告)号：EP2938596A1
公开(公告)日：2015-11-04
申请号：EP13822069.4
申请日：2013-12-27
发明人： PANDEY, Anjali , ROSE, Jack, W.
IPC分类号： C07D213/75
CPC分类号： C12N9/6432 , B01D15/38 , B01D15/3804 , C07D213/75 , C07D221/06
摘要： Disclosed herein are compounds, compositions, methods and kits for purifying a protease and serine proteases purified with the compounds, compositions and methods.
摘要翻译： 本文公开了用于纯化丝氨酸蛋白酶和用化合物，组合物和方法纯化的丝氨酸蛋白酶的化合物，组合物，方法和试剂盒。
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5.发明授权2,6-DIAMINO-PYRIMIDIN-5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS 有权2,6-二氨基 - 嘧啶-5-基甲酰胺于或SYK激酶JAK抑制剂
公开(公告)号：EP2321283B1
公开(公告)日：2016-07-13
申请号：EP09755219.4
申请日：2009-04-16
发明人： BAUER, Shawn, M. , JIA, Zhaozhong, J. , SONG, Yonghong , XU, Qing , MEHROTRA, Mukund , ROSE, Jack, W. , HUANG, Wolin , VENKATARAMANI, Chandrasekar , PANDEY, Anjali
IPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61P35/00 , A61P9/00 , A61K31/506
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.
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6.发明公开2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS 有权2,6-二氨基嘧啶-5-基羧酰胺于或Syk激酶JAK抑制剂
公开(公告)号：EP2323993A2
公开(公告)日：2011-05-25
申请号：EP09742982.3
申请日：2009-04-16
发明人： JIA, Zhaozhong, J. , VENKATARAMANI, Chandrasekar , HUANG, Wolin , MEHROTRA, Mukund , SONG, Yonghong , XU, Qing , BAUER, Shawn, M. , PANDEY, Anjali , KANE, Brian , ROSE, Jack, W.
IPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61P35/00 , A61P9/00 , A61K31/506 , C07D407/12 , C07D409/12
CPC分类号： A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of formula I-V and tattooers thereof or pharmaceutically acceptable salts, esters, and pro drugs thereof which are inhibitors of sky kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
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