发明公开
- 专利标题： PROCESS FOR PREPARING AZACYTIDINE INTERMEDIATE
- 专利标题（中）： 制备阿扎地米中间体的方法
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申请号： EP09791228.1申请日： 2009-08-06
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公开(公告)号： EP2324042A1公开(公告)日： 2011-05-25
- 发明人: BIGATTI, Ettore , LUX, Giovanna , PAIOCCHI, Maurizio , GIOLITO, Andrea , TOSI, Simone
- 申请人： Sicor, Inc.
- 申请人地址： 19 Hughes Irvine, CA 92618 US
- 专利权人： Sicor, Inc.
- 当前专利权人： Sicor, Inc.
- 当前专利权人地址： 19 Hughes Irvine, CA 92618 US
- 代理机构： King, Lawrence
- 优先权： US146112P 20090121; US178309P 20090514; US86606P 20080806
- 国际公布： WO2010017374 20100211
- 主分类号： C07H19/12
- IPC分类号： C07H19/12 ; C07H1/00 ; A61K31/706
摘要：
The present invention provides a processes for preparing 5 -Azacytidine, and intermediates thereof, said process Comprising reacting a silylated 5-azacytosine of the formula (II), a sugar moiety having of the formula (III): and a protic acid; wherein R is a substituted or non substituted C
1 -C
20 acyl moiety, R
1 , R
2 and R
3 are each independently H or an alkyl group, and X is a halogen. The present invention further provides an analytical method for determining the purity of 5-Azacytidine in a sample.
1 -C
20 acyl moiety, R
1 , R
2 and R
3 are each independently H or an alkyl group, and X is a halogen. The present invention further provides an analytical method for determining the purity of 5-Azacytidine in a sample.
公开/授权文献
- EP2324042B1 PROCESS FOR PREPARING AZACYTIDINE INTERMEDIATE 公开/授权日：2012-11-28
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