发明公开
EP2326653A1 NEW (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS
有权
NEW（POLY）表鬼臼毒素AMINOALKYLAMINOALKYLHARNSTOFF-衍生物，加工生产和使用在治疗中用作抗恶性肿瘤药
- 专利标题： NEW (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS
- 专利标题（中）： NEW（POLY）表鬼臼毒素AMINOALKYLAMINOALKYLHARNSTOFF-衍生物，加工生产和使用在治疗中用作抗恶性肿瘤药
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申请号： EP09782006.2申请日： 2009-08-19
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公开(公告)号： EP2326653A1公开(公告)日： 2011-06-01
- 发明人: IMBERT, Thierry , GUMINSKI, Yves , BARRET, Jean-Marc , KRUCZYNSKI, Anna
- 申请人： Pierre Fabre Medicament
- 申请人地址： 45, Place Abel Gance 92100 Boulogne-Billancourt FR
- 专利权人： Pierre Fabre Medicament
- 当前专利权人： Pierre Fabre Medicament
- 当前专利权人地址： 45, Place Abel Gance 92100 Boulogne-Billancourt FR
- 代理机构： Ahner, Francis
- 优先权： FR0855629 20080819
- 国际公布： WO2010020663 20100225
- 主分类号： C07D493/04
- IPC分类号： C07D493/04 ; A61K31/36 ; A61P35/00
摘要：
The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamidc, or alkyl-urea or alkyl- sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: - R represents hydrogen or C
1-4 alkyI, - A represents CO(CH
2 )
n or CONH(CH
2 )
n where n = 2, 3, 4, or 5, - R1 and R2 are as described herein.
1-4 alkyI, - A represents CO(CH
2 )
n or CONH(CH
2 )
n where n = 2, 3, 4, or 5, - R1 and R2 are as described herein.
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