摘要:
The invention concerns novel fluorinated imidazoline benzodioxane, their preparation and their therapeutic uses. More particularly, the invention concerns compounds corresponding to the structure of general formula (1) wherein: R represents a linear alkyl or alkenyl group, branched of cyclised, comprising 1 to 7 carbon atoms, or a benzyl group, and the fluorine atom can be in position 5, 6, 7 or 8, in their racemic form or their pure enantiomeric forms, dextro-rotatory or laevo-rotatory, and their additive salts.
摘要:
The invention concerns 2-aminomethyl-benzo[a]quinolizidine derivatives, corresponding to general formula (I) in which: R1 represents either a hydrogen atom or a branched, linear or cyclic C1-C4 alkyl group, a branched, linear or cyclic C1-C4 hydroxy or alkoxy group, or a halogen atom such as F or Cl; R2 represents a hydrogen atom or a C1-C6 alkyl group; R3 represents a hydrogen atom or can constitute a unit (C=X)-NR4R5 and in that case constitutes a urea or thiourea with X = oxygen or sulphur; R4 and R5 can independently be a hydrogen atom or a linear, branched, cyclic C1-C8 alkyl group, an aryl, aralkyl, aroyl group, said aryl groups capable of being substituted as well; R4 and R5 can be bound by a carbon chain optionally incorporating a heteroatom.
摘要:
Use of a compound of general formula (I) wherein R1 is a hydrogen atom, a linear or branched C1-C6 alkyl radical, R2 is a hydrogen atom, a methyl, chloro, bromo or fluoro group, and R3 is a hydrogen atom, a methyl, hydroxy, methoxy, fluoro, chloro or bromo group, and its therapeutically acceptable salts, its racemic or optically active isomers, for the preparation of a drug for treating Alzheimer-like senile dementia, pre-Alzheimer syndrome, progressive supranuclear palsy and other neurodegenerative diseases.
摘要:
The invention concerns the use of complex efaroxan of formula (I) and its therapeutically acceptable salts, of its racemic form or of its optically active isomers, for preparing a medicine for treating Huntington disease.
摘要:
Compound of the general formula (I) in which R' is a hydrogen atom or a radical R and R is an acyl residue. The invention also concerns a process for the preparation of said compound, the use of said compound as a drug and in the preparation of a drug for treating cancer. A pharmaceutical composition comprising said compound is also disclosed.
摘要:
Use of a compound of general formula (I), wherein R is a hydrogen atom, a linear or branched C1-C4 alkyl radical or a linear or branched C1-C4 alkoxy radical, and its therapeutically acceptable salts, its racemic form or its optically active isomers. Said compound is useful in the preparation of a drug intended for use in the treatment of Alzheimer-type senility and pre-Alzheimer syndrome and the prevention of the progression of these diseases.
摘要:
A compound of general formula (I), wherein R is a hydrogen atom, a straight or branched C1-4 alkyl radical or a straight or branched C1-4 alkoxy radical; and therapeutically acceptable salts, a racemic mixture or optically active isomers thereof; is used to prepare a drug for treating Parkinson's disease and its development.
摘要:
The invention relates to a crystalline compound of 4'-demethyl-4'-phosphate-2",3"-bispentafluorophenoxyacetyl-4",6"-ethylidene- beta -D-epipodophyllotoxin glucoside in its free form or solvated with ethanol, advantageously provided in the form of a hemiethanolate solvate. The invention also relates to a method for preparing these compounds and to their use as an anticancer drug.
摘要:
The invention concerns the use of complex efaroxan of formula (I) and its therapeutically acceptable salts, of its racemic form or of its optically active isomers, for preparing a medicine for treating Huntington disease.
摘要:
The present invention relates to a method for the production of 4'-demethyl -4'- phosphate-2',3' -bispentafluorophenoxyacetyl - 4',6'-ethylidene - β-D-glucoside epipodophyllotoxin, characterized in that 2,3-bis pentafluorophenoxyacetyl-1-O-triethylsilyl-β-D-glucopyranoside is condensed with 4'-demethyl-4'-aryloxyacetyl-epipodophyllotoxin.