DERIVES D'AMINOMETHYL-BENZO A]QUINOLIZIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE POUR LES MALADIES NEURODEGENERATIVES
    2.
    发明公开
    DERIVES D'AMINOMETHYL-BENZO A]QUINOLIZIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE POUR LES MALADIES NEURODEGENERATIVES 审中-公开
    AMINOMETHYLBENZOCHINOLIZIDINDERIVATE,制备方法及其使用的神经退行性疾病的治疗

    公开(公告)号:EP1027350A1

    公开(公告)日:2000-08-16

    申请号:EP98951548.1

    申请日:1998-10-26

    IPC分类号: C07D455/06 A61K31/435

    CPC分类号: C07D455/06

    摘要: The invention concerns 2-aminomethyl-benzo[a]quinolizidine derivatives, corresponding to general formula (I) in which: R1 represents either a hydrogen atom or a branched, linear or cyclic C1-C4 alkyl group, a branched, linear or cyclic C1-C4 hydroxy or alkoxy group, or a halogen atom such as F or Cl; R2 represents a hydrogen atom or a C1-C6 alkyl group; R3 represents a hydrogen atom or can constitute a unit (C=X)-NR4R5 and in that case constitutes a urea or thiourea with X = oxygen or sulphur; R4 and R5 can independently be a hydrogen atom or a linear, branched, cyclic C1-C8 alkyl group, an aryl, aralkyl, aroyl group, said aryl groups capable of being substituted as well; R4 and R5 can be bound by a carbon chain optionally incorporating a heteroatom.